33445-07-7

Basic information

• Product Name: isopropoxyacetic acid
• Synonyms: isopropoxyacetic acid;UKRORGSYN-BB BBV-083156;acetic acid, (1-methylethoxy)-;isopropoxyacetic acid(SALTDATA: FREE);2-isopropoxyaceticacid;Acetic acid, 2-(1-methylethoxy)-;2-propan-2-yloxyacetic acid;2-propan-2-yloxyethanoic acid
• CAS NO: 33445-07-7
• Molecular Formula: C₅H₁₀O₃
• Molecular Weight: 118.13
• Mol File: 33445-07-7.mol
• Article Data: 18

Chemical Properties

• Boiling Point: 214.5°C at 760 mmHg
• Flash Point: 89.6°C
• Appearance: /
• Density: 1.05g/cm³
• Vapor Pressure: 0.0601mmHg at 25°C
• Refractive Index: 1.42
• PKA: 3.49±0.10(Predicted)
• CAS DataBase Reference: isopropoxyacetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: isopropoxyacetic acid(33445-07-7)
• EPA Substance Registry System: isopropoxyacetic acid(33445-07-7)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 33445-07-7(Hazardous Substances Data)

Usage

General Description

Isopropoxyacetic Acid, also known as 2-Propanol, 1-(acetyloxy)-, and 541-94-0, is a chemical compound mostly used in industrial applications. While the scientific understanding of its properties is incomplete, it is known that it derives from an acetic acid and isopropanol. It is considered a moderately hazardous substance due to its potential to irritate the skin and eyes and cause respiratory discomfort if inhaled. There isn't a comprehensive understanding of its environmental impact, but like many industrial chemicals, proper handling to minimize its release into the environment is essential.

InChI:InChI=1/C5H10O3/c1-4(2)8-3-5(6)7/h4H,3H2,1-2H3,(H,6,7)

Upstream product

• 79-08-3 bromoacetic acid 
• 67-63-0 isopropyl alcohol 
• 1089707-47-0 tert-butyl 2-isopropoxyacetate 
• 17639-74-6 isopropyl 2-isopropoxyacetate 
• 3926-62-3 sodium monochloroacetic acid 
• 683-60-3 sodium isopropylate 
• 105-36-2 ethyl bromoacetate 
• 79-11-8 chloroacetic acid 

Downstream Products

• 60359-63-9 Isopropoxy-acetic acid 2-phenoxy-ethyl ester 
• 4346-01-4 formaldehyde t-butyl isopropyl acetal 
• 50-00-0 formaldehyd 
• 187737-37-7 propene 
• 67-63-0 isopropyl alcohol 
• 475480-81-0 (S)-2-Isopropoxy-3-{4-[2-(5-methyl-2-phenyl-oxazol-4-yl)-ethoxy]-benzo[b]thiophen-7-yl}-propionic acid 
• 1193615-74-5 C₁₄H₁₉O₆P 

Relevant articles and documents

N-(3-(2-(4-CHLOROPHENOXY)ACETAMIDO)BICYCLO[1.1.1]PENTAN-1-YL)-2-CYCLOBUTANE-1-CARBOXAMIDE DERIVATIVES AND RELATED COMPOUNDS AS ATF4 INHIBITORS FOR TREATING CANCER AND OTHER DISEASES

The invention is directed to substituted bridged cycloalkane derivatives. Specifically, the invention is directed to compounds according to Formula (I) wherein X, a, b, C, D, L2,L3, Y1, Y2, R2, R4, R5, R6, z2, z4, z5, and z6 are as defined herein, and salts thereof. The invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to compounds for use in methods of inhibiting the ATF4 (activating transcription factor 4) pathway and treatment of disorders associated therewith, such as e.g. cancer, neurodegenerative diseases and many other diseases, using a compound of the invention or a pharmaceutical composition comprising a compound of the invention. Preferred compounds of the invention are N-(3-(2-(4-chlorophenoxy) acetamido)bicyclo[1.1.1]pentan-l-yl)-2-cyclobutane-l-carboxamide derivatives and related compounds.

Larvicidal activity and click synthesis of 2-alkoxyl-2-(1,2,3-triazole-1- yl)acetamide library

Heterogeneous copper-in-charcoal-catalyzed click synthesis in 96-well polypropylene filter plates is an efficient method for the rapid generation of sufficient pure 2-alkoxyl-2-(1,2,3-triazole-1-yl) acetamide derivatives library by simple filtration, which directly assay the products for larvicidal activity against mosquitoes. In this procedure, copper nanoparticles on charcoal were arrayed into each well on a 96-well plate, reagents were delivered using a pipette gun, and a constant temperature shaker bath was used to complete the click reaction in 24-72 hours under temperature-controlled conditions. The results of bioassays indicated that the target compounds possessed excellent larvacidal activities against mosquitoes. In particular, the larvacidal activities against mosquitoes of compounds 8[2,3] and 8[7,1] at 2g.mL-1 were 100% and 73%, respectively.

Asymmetric hydrogenation of α- Or β-acyloxy α,β- unsaturated phosphonates catalyzed by a Rh(i) complex of monodentate phosphoramidite

The Rh(i) complex of a monodentate phosphoramidite bearing a primary amine moiety (DpenPhos) has been disclosed to be highly efficient for the asymmetric hydrogenation of a variety of α- or β-acyloxy α,β- unsaturated phosphonates, providing the corresponding biologically important chiral α- or β-hydroxy phosphonic acid derivatives with excellent enantioselectivities (90->99% ee).