334537-39-2

Basic information

• Product Name: ethyl 2-{{2-{{2-{{2-{[(benzyloxy)carbonyl]amino}-2-methyl-1-oxopropyl}amino}-2-methyl-1-oxopropyl}amino}-2-methyl-1-oxopropyl}amino}-2-methylpropanoate
• CAS NO: 334537-39-2
• Molecular Weight: 520.626
• Mol File: 334537-39-2.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: ethyl 2-{{2-{{2-{{2-{[(benzyloxy)carbonyl]amino}-2-methyl-1-oxopropyl}amino}-2-methyl-1-oxopropyl}amino}-2-methyl-1-oxopropyl}amino}-2-methylpropanoate(CAS DataBase Reference)
• NIST Chemistry Reference: ethyl 2-{{2-{{2-{{2-{[(benzyloxy)carbonyl]amino}-2-methyl-1-oxopropyl}amino}-2-methyl-1-oxopropyl}amino}-2-methyl-1-oxopropyl}amino}-2-methylpropanoate(334537-39-2)
• EPA Substance Registry System: ethyl 2-{{2-{{2-{{2-{[(benzyloxy)carbonyl]amino}-2-methyl-1-oxopropyl}amino}-2-methyl-1-oxopropyl}amino}-2-methyl-1-oxopropyl}amino}-2-methylpropanoate(334537-39-2)

Safety Data

• Hazardous Substances Data: 334537-39-2(Hazardous Substances Data)

Upstream product

• 334537-38-1 ethyl [(benzyloxy)carbonyl]-dimethylglycyl-dimethylglycyl-dimethylglycinate 
• 334537-37-0 ethyl [(benzyloxy)carbonyl]-dimethylglycyl-dimethylglycinate 
• 334537-44-9 H-(Aib)₂-OEt 
• 1113-49-1 2-methylalanine ethyl ester 
• 15030-72-5 Z-Aib-OH 

Relevant articles and documents

Conformational Study of Heteropentapeptides Containing an α-Ethylated α,α-Disubstituted Amino Acid: (S)-Butylethylglycine (=2-Amino-2-ethylhexanoic Acid) within a Sequence of Dimethylglycine (= 2-Aminoisobutyric Acid) Residues

Heteropentapeptides containing the α-ethylated α,α-disubstituted amino acid (S)-butylethylglycine and four dimethylglycine residues, i.e., CF3CO-[(S)-Beg]-(Aib)4-OEt (4) and CF3CO-(Aib)2-[(S)-Beg]-(Aib)2OEt (7), were synthesized by conventional solution methods. In the solid state, the preferred conformation of 4 was shown to be both a right-handed (P) and a left-handed (M) 310-helical structure, and that of 7 was a right-handed (P) 310-helical structure. IR, CD, and 1H-NMR spectra revealed that the dominant conformation of both 4 and 7 in solution was the 310-helical structure. These conformations were also supported by molecular-mechanics calculations.