33468-67-6

Basic information

• Product Name: 2-Methyl-4-trifluoromethylimidazole
• Synonyms: 2-methyl-4-(trifluoromethyl)-1H-imidazole;2-METHYL-4-TRIFLUOROMETHYLIMIDAZOLE;2-Methyl-4-(trifluoroMethyl)-2H-iMidazole;2-Methyl-5-(trifluoromethyl)-1H-imidazole
• CAS NO: 33468-67-6
• Molecular Formula: C₅H₅F₃N₂
• Molecular Weight: 150.1
• Product Categories: Heterocycle
• Mol File: 33468-67-6.mol
• Article Data: 11

Chemical Properties

• Melting Point: 179-180 °C
• Boiling Point: 249 °C
• Flash Point: 105 °C
• Appearance: /
• Density: 1.355
• Vapor Pressure: 0.0362mmHg at 25°C
• Refractive Index: 1.429
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 10.84±0.10(Predicted)
• CAS DataBase Reference: 2-Methyl-4-trifluoromethylimidazole(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Methyl-4-trifluoromethylimidazole(33468-67-6)
• EPA Substance Registry System: 2-Methyl-4-trifluoromethylimidazole(33468-67-6)

Safety Data

• Hazard Codes: T
• Statements: 25
• Safety Statements: 45
• RIDADR: UN 2811 6.1 / PGIII
• HazardClass: IRRITANT
• Hazardous Substances Data: 33468-67-6(Hazardous Substances Data)

Usage

General Description

2-Methyl-4-trifluoromethylimidazole is a chemical compound that is commonly used as an intermediate in the synthesis of pharmaceuticals, agrochemicals, and dyes. It is a colorless liquid with a molecular formula of C5H5F3N2 and a molecular weight of 150.1 g/mol. 2-Methyl-4-trifluoromethylimidazole is known for its strong basic properties and is often used as a catalyst in organic synthesis reactions. It is also used as a building block in the production of various types of pharmaceuticals, making it a highly important compound in the pharmaceutical industry. Additionally, it has applications in the production of agrochemicals and dyes, further highlighting its versatility and significance in the chemical industry.

InChI:InChI=1/C5H5F3N2/c1-3-9-2-4(10-3)5(6,7)8/h2H,1H3,(H,9,10)

Upstream product

• 693-98-1 2-methylimidazole 
• 1184-76-5 difluorodiiodomethane 
• 75-07-0 acetaldehyde 
• 431-67-4 1,1-dibromo-3,3,3-trifluoroacetone 
• 2314-97-8 iodotrifluoromethane 
• 91944-47-7 3,3,3-Trifluoropyruvaldehyde 
• 2926-29-6 Langlois reagent 

Downstream Products

• 112108-86-8 2-methyl-1H-imidazole-4-carbonitrile 
• 1616384-56-5 (2S)-N-[1-(4-chlorophenyl)-5-cyclobutyl-pyrazol-4-yl]-2-[2-methyl-4-(trifluoromethyl)imidazol-1-yl]propanamide 
• 1616461-18-7 (S)-N-(1-(4-chlorophenyl)-5-isopropyl-1H-pyrazol-4-yl)-2-(2-methyl-4-(trifluoromethyl)-1H-imidazol-1-yl)propanamide 
• 1616384-75-8 C₁₆H₁₈F₃N₃O₂ 
• 1616384-46-3 N-[5-ethoxy-1-(4-fluorophenyl)pyrazol-4-yl]-2-[2-methyl-4-(trifluoromethyl)imidazol-1-yl]propanamide 
• 1613395-48-4 C₁₉H₁₉F₄N₅O₄S 
• 1613395-47-3 C₁₈H₁₇F₄N₅O₂ 
• 1613394-89-0 1-[1-(4-fluorophenyl)pyrazol-4-yl]-3-[2-methyl-4-(trifluoromethyl)imidazol-1-yl]pyrrolidin-2-one 
• 1613396-79-4 C₂₃H₂₇ClF₃N₅O₅S 
• 1613396-77-2 C₂₂H₂₅ClF₃N₅O₃ 
• 1613395-34-8 (3S)-1-[1-(4-chloro-3-methoxy-phenyl)-5-isopropyl-pyrazol-4-yl]-3-[2-methyl-4-(trifluoromethyl)imidazol-1-yl]pyrrolidin-2-one 
• 1613395-33-7 1-[1-(4-chlorophenyl)-5-cyclobutyl-pyrazol-4-yl]-3-[2-methyl-4-(trifluoromethyl)imidazol-1-yl]pyrrolidin-2-one 
• 1613396-53-4 [(3S)-4-[[1-(4-chlorophenyl)-5-isopropyl-triazol-4-yl]amino]-3-[2-methyl-4-(trifluoromethyl)imidazol-1-yl]-4-oxo-butyl]methanesulfonate 
• 1613396-51-2 (2S)-N-[1-(4-chlorophenyl)-5-isopropyl-triazol-4-yl]-4-hydroxy-2-[2-methyl-4-(trifluoromethyl)imidazol-1-yl]butanamide 

Relevant articles and documents

CATALYST-FREE AND REDOX-NEUTRAL INNATE TRIFLUOROMETHYLATION AND ALKYLATION OF (HETERO)AROMATICS ENABLED BY LIGHT

The present disclosure relates to reagents and method for performing trifluoromethylation, difluoromethylation or alkylation of aromatic or heteroaromatic rings in a redox-neutral manner without any catalyst which are enabled by light. In addition, there are methods for synthesizing the starting reagents used in the trifluoromethylation, difluoromethylation or alkylation reactions.

Simple and Clean Photoinduced Aromatic Trifluoromethylation Reaction

We describe a simple, metal-and oxidant-free photochemical strategy for the direct trifluoromethylation of unactivated arenes and heteroarenes under either ultraviolet or visible light irradiation. We demonstrated that photoexcited aliphatic ketones, such as acetone and diacetyl, can be used as promising low-cost radical initiators to generate CF3 radicals from sodium triflinate efficiently. The broad utility of this strategy and its benefit to medicinal chemistry are demonstrated by the direct trifluoromethylation of unprotected bidentate chelating ligand, xanthine alkaloids, nucleosides, and related antiviral drug molecules.

HETEROCYCLIC MODULATORS OF LIPID SYNTHESIS

Heterocyclic modulators of lipid synthesis are provided as well as pharmaceutically acceptable salts thereof; pharmaceutical compositions comprising such compounds; and methods of treating conditions characterized by disregulation of a fatty acid synthase pathway by the administration of such compounds.