335-08-0

Basic information

• Product Name: 1,1,1-TRIFLUOROACETONE CYANOHYDRIN
• Synonyms: 1,1,1-TRIFLUOROACETONE CYANHYDRIN;1,1,1-TRIFLUOROACETONE CYANOHYDRIN;3,3,3-TRIFLUORO-2-HYDROXY-2-METHYLPROPANENITRILE;2-HYDROXY-2-(TRIFLUOROMETHYL)PROPIONITRILE;TRIFLUOROACETONE CYANOHYDRIN;2-Cyano-1,1,1-trifluoro-2-propanol~2-Hydroxy-2-(trifluoromethyl)propionitrile;2-HYDROXY-2-(TRIFLUOROMETHYL)PROPIO- &;1,1,1-Trifluoroacetonecyanohydrine
• CAS NO: 335-08-0
• Molecular Formula: C₄H₄F₃NO
• Molecular Weight: 139.08
• EINECS: -0
• Mol File: 335-08-0.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 68 °C
• Flash Point: 60°C
• Appearance: /
• Density: 1,276 g/cm3
• Refractive Index: 1.338
• PKA: 8.67±0.29(Predicted)
• Water Solubility: Fully miscible in water.
• Sensitive: Moisture Sensitive
• BRN: 1758723
• CAS DataBase Reference: 1,1,1-TRIFLUOROACETONE CYANOHYDRIN(CAS DataBase Reference)
• NIST Chemistry Reference: 1,1,1-TRIFLUOROACETONE CYANOHYDRIN(335-08-0)
• EPA Substance Registry System: 1,1,1-TRIFLUOROACETONE CYANOHYDRIN(335-08-0)

Safety Data

• Hazard Codes: T,Xn
• Statements: 26/27/28-50/53-20/21/22
• Safety Statements: 7/9-27-45-60-61-36/37
• RIDADR: 3276
• HazardClass: 6.1
• PackingGroup: II
• Hazardous Substances Data: 335-08-0(Hazardous Substances Data)

Usage

Uses

A chlorinated acetone derivative for organic synthesis and proteomics research

Upstream product

• 421-50-1 1,1,1-trifluoro-2-propanone 
• 151-50-8 potassium cyanide 
• 143-33-9 sodium cyanide 
• 773837-37-9 sodium cyanide 

Downstream Products

• 4588-51-6 rac-2-cyano-1,1,1-trifluoroprop-2-yl acetate 
• 114645-34-0 (R,S)-3,3,3-trifluoro-2-hydroxy-2-methylpropionamide 
• 381-84-0 2-(trifluoromethyl)acrylonitrile 
• 374-35-6 3,3,3-trifluoro-2-hydroxy-2-methylpropionic acid 

Relevant articles and documents

2-Trifluoromethyl-2-Hydroxypropionamide Derivatives as Novel Reversal Agents of ABCG2 (BCRP)-Mediated Multidrug Resistance: Synthesis and Biological Evaluations

It has been postulated that one of the biggest impediments to a successful chemotherapy is the phenomena of multidrug resistance (MDR) in cancer cells. One of the main mechanisms of MDR is overexpression of the ATP-binding cassette (ABC) transporters in c

Oxazolones as potent inhibitors of 11β-hydroxysteroid dehydrogenase type 1

2,5,5-Trisubstituted oxazolones were identified as potent inhibitors of 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1). The synthesis, structure-activity relationship and metabolic stability of these compounds are presented.