335428-62-1

Basic information

• Product Name: 5-bromo-2,3-dihydro-1-methyl-1H-Isoindole
• Synonyms: 5-bromo-2,3-dihydro-1-methyl-1H-Isoindole;5-bromo-1-methylisoindoline;5-Bromo-1-methyl-2,3-dihydro-1H-isoindole;1H-Isoindole,5-bromo-2,3-dihydro-1-methyl-;1-Methyl-5-(4,4,5,5-tetramethyl-[1,3,2]dioxaborolan-2-yl)-2,3-dihydro-1H-isoindole
• CAS NO: 335428-62-1
• Molecular Formula: C9H10BrN
• Molecular Weight: 212.09
• Mol File: 335428-62-1.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 261.1 °C at 760 mmHg
• Flash Point: 111.7 °C
• Appearance: /
• Density: 1.407 g/cm³
• Vapor Pressure: 0.0118mmHg at 25°C
• Refractive Index: 1.571
• CAS DataBase Reference: 5-bromo-2,3-dihydro-1-methyl-1H-Isoindole(CAS DataBase Reference)
• NIST Chemistry Reference: 5-bromo-2,3-dihydro-1-methyl-1H-Isoindole(335428-62-1)
• EPA Substance Registry System: 5-bromo-2,3-dihydro-1-methyl-1H-Isoindole(335428-62-1)

Safety Data

• Hazardous Substances Data: 335428-62-1(Hazardous Substances Data)

Usage

General Description

5-bromo-2,3-dihydro-1-methyl-1H-Isoindole is a chemical compound with the molecular formula C9H10BrN. It is a derivative of isoindole, and its structure includes a bromine atom and a methyl group attached to the isoindole ring. 5-bromo-2,3-dihydro-1-methyl-1H-Isoindole is used in organic synthesis and pharmaceutical research as a building block and intermediate for the preparation of various organic compounds and drugs. It is known for its potential pharmacological activities and is being studied for its potential use in the treatment of various medical conditions. However, further research is needed to fully understand its properties and potential applications.

InChI:InChI=1/C9H10BrN/c1-6-9-3-2-8(10)4-7(9)5-11-6/h2-4,6,11H,5H2,1H3

Upstream product

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• 75-07-0 acetaldehyde 
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• 29879-70-7 3-hydroxy-3-methylisoindolin-1-one 
• 136918-14-4 phthalimide 
• 3886-69-9 (R)-1-phenyl-ethyl-amine 
• 24358-62-1 (R)-1-(4-bromophenyl)ethylamine 
• 64-19-7 acetic acid 
• 99-90-1 para-bromoacetophenone 

Relevant articles and documents

Synthesis method of garafloxacin intermediate

The invention discloses a synthesis method of a garafloxacin intermediate (1R)-5-bromo-2, 3-dihydro-1-methyl-1H-isoindole; the synthesis method comprises the following steps of: taking a garafloxacin intermediate as a raw material; the method comprises the following steps: step 1, by taking R(+)-alpha-phenylethylamine as a raw material and lewis acid as a catalyst, carrying out bromine bromination reaction to obtain a compound 2; 2, placing the compound 2 in a solvent, adding hydrochloric acid, paraformaldehyde and a catalyst, and carrying out chloromethylation reaction to obtain a compound 3; 3, dissolving the compound 3 in a solvent, adding alkali, and heating the mixture for reaction to obtain a compound 1. The method is simple in reaction, short in route, less in three wastes, environment-friendly, high in yield of each step, less in waste of raw materials and reagents, and especially suitable for industrial production.

Traceless Directing Group Assisted Cobalt-Catalyzed C?H Carbonylation of Benzylamines

The first example of cobalt-catalyzed C(sp2)?H carbonylation of benzylamines using a traceless directing group is reported, which was successfully applied to the synthesis of N?unprotected iso-indolinones through direct C?H/N?H bonds activation. This protocol tolerates a variety of functional groups and provides a facile and efficient method for the formal synthesis of (+)-garenoxacin. (Figure presented.).

NOVEL COMPOUND WITH ANTIBACTERIAL ACTIVITY

A compound represented by the general formula (I) or a salt thereof having a potent antibacterial activity against bacteria that have acquired resistance to quinolones, and a medicament for prophylactic and/or therapeutic treatment of an infectious disease containing the compound or a salt thereof as an active ingredient, as well as a medicament for prophylactic and/or therapeutic treatment of an infectious disease containing a combination of the compound or a salt thereof, and a quinolone.