3356-89-6

Basic information

• Product Name: 5-chloro-3-phenyl-oxazole
• Synonyms: 5-chloro-3-phenyl-oxazole;3-Phenyl-5-chloroisoxazole;Isoxazole, 5-chloro-3-phenyl-;Nsc295879
• CAS NO: 3356-89-6
• Molecular Formula: C₉H₆ClNO
• Molecular Weight: 179.61
• Mol File: 3356-89-6.mol
• Article Data: 10

Chemical Properties

• Melting Point: 51-52℃
• Boiling Point: 314.5 °C at 760 mmHg
• Flash Point: 144 °C
• Appearance: /
• Density: 1.258±0.06 g/cm3 (20 ºC 760 Torr)
• Vapor Pressure: 0.000857mmHg at 25°C
• Refractive Index: 1.559
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: -4.43±0.50(Predicted)
• CAS DataBase Reference: 5-chloro-3-phenyl-oxazole(CAS DataBase Reference)
• NIST Chemistry Reference: 5-chloro-3-phenyl-oxazole(3356-89-6)
• EPA Substance Registry System: 5-chloro-3-phenyl-oxazole(3356-89-6)

Safety Data

• Hazardous Substances Data: 3356-89-6(Hazardous Substances Data)

Usage

General Description

5-chloro-3-phenyl-oxazole is a chemical compound classified under the group of oxazole compounds which are heterocyclic compounds. This specific chemical contains chlorine (Cl) and phenyl group attached to the oxazole ring which makes it unique and imparts specific properties to it. The phenyl group gives aromatic characteristics to the compound, and the chlorine atom can significantly influence its reactivity and interactions. While the detailed properties and potential uses of 5-chloro-3-phenyl-oxazole are not widely studied or documented, it may presumably have applications in the field of organic synthesis, medicinal chemistry or chemical research due to its structural aspects and the overall significance of oxazole compounds.

InChI:InChI=1/C9H6ClNO/c10-9-6-8(11-12-9)7-4-2-1-3-5-7/h1-6H

Upstream product

• 1076-59-1 3-phenyl-4H-isoxazol-5-one 
• 2415-80-7 1,1-dichloro-2-phenylcyclopropane 
• 10562-42-2 3,3-dichloro-1-phenyl-propenone 
• 873-67-6 benzonitrile oxide 
• 540-59-0 1,2-Dichloroethylene 
• 94-02-0 ethyl 3-oxo-3-phenylpropionate 
• 75-35-4 1,1-Dichloroethylene 
• 698-16-8 benzohydroximoyl chloride 

Downstream Products

• 62847-61-4 5-pent-4-enyloxy-3-phenyl-isoxazole 
• 23244-34-0 5-ethoxy-3-phenylisoxazole 
• 25755-81-1 5-butylsulfanyl-3-phenyl-isoxazole 
• 62847-62-5 5-(2-ethylsulfanyl-ethoxy)-3-phenyl-isoxazole 
• 25755-80-0 3-phenyl-5-methylthio-isoxazole 
• 62847-69-2 4-allyl-3-phenyl-2H-isoxazol-5-one 
• 27025-89-4 5-i-propyloxy-3-phenylisoxazole 
• 13626-89-6 5-ethylsulfanyl-3-phenyl-isoxazole 
• 27025-90-7 5-tert-butoxy-3-phenylisoxazole 
• 23893-62-1 5-n-butyloxy-3-phenylisoxazole 
• 27133-14-8 5-chloro-4-iodo-3-phenyl-isoxazole 
• 18803-02-6 5-methoxy-3-phenylisoxazole 
• 18709-45-0 methyl 3-phenyl-2H-azirine-2-carboxylate 

Relevant articles and documents

Synthesis of 5-Chloroisoxazoles Derived from 2,2-Dichlorovinyl Ketones

Abstract: The reactions of 2,2-dichlorovinyl ketones with hydroxylamine hydrochloride give the corresponding oximes. The subsequent heterocyclization of the latter under the action of t-BuOK in t-BuOH results in selective formation of 5-chloro-3-alkyl- or

Nitrosylsulfuric acid in the synthesis of 5-chloroisoxazoles from 1,1-dichlorocyclopropanes

Nitrosylsulfuric acid is shown to be a usable reagent for the synthesis of 5-chloroisoxazoles from readily available 1,1-di-chlorocyclopropanes via nitrosation–heterocyclization reaction. A cytotoxicity of some of the prepared 5-chloroisoxazoles towards M

Transformations of gem-dichloroarylcyclopropanes in the reaction with NOCl·2SO3. Synthesis of 3-aryl-5-chloroisoxazoles

Nitrosation with complex NOCl·2SO3 of gem-dichloroarylcyclopropanes containing acceptor substituents in the aromatic ring proceeded chemo- and regioselectively affording 3-aryl-5-chloroisoxazoles in high yields. The presence of donor substituents complicated the reaction by the occurrence of competing processes.