335649-84-8 Usage
Molecular structure
1H-Indole-1-carboxylic acid, 2-borono-5-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-, 1,1-dimethylethyl ester is a derivative of indole-1-carboxylic acid with a boronic ester and a silyl ether group attached to the core structure.
Functional groups
The compound contains a carboxylic acid group (-COOH), a boronic ester group (-B(OH)2), and a silyl ether group (-SiR3) as its key functional groups.
Reactivity
The presence of the boronic ester group makes the compound suitable for use in Suzuki-Miyaura cross-coupling reactions, a widely used method in organic synthesis.
Versatility
The ester functional group in the compound can be readily hydrolyzed to the corresponding carboxylic acid, making it a versatile building block for the synthesis of various drug candidates.
Protection
The presence of a silyl ether moiety in the molecule can provide protection to sensitive functional groups during chemical transformations.
Pharmaceutical applications
The compound has potential pharmaceutical applications due to its unique structure and reactivity, making it a valuable intermediate in the development of new pharmaceuticals.
Check Digit Verification of cas no
The CAS Registry Mumber 335649-84-8 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,3,5,6,4 and 9 respectively; the second part has 2 digits, 8 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 335649-84:
(8*3)+(7*3)+(6*5)+(5*6)+(4*4)+(3*9)+(2*8)+(1*4)=168
168 % 10 = 8
So 335649-84-8 is a valid CAS Registry Number.
InChI:InChI=1/C20H32BNO5Si/c1-19(2,3)27-18(23)22-16-10-9-14(11-15(16)12-17(22)21(24)25)13-26-28(7,8)20(4,5)6/h9-12,24-25H,13H2,1-8H3
335649-84-8Relevant articles and documents
INDOLYL-PYRIDONE DERIVATIVES
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Page/Page column 20; 28; 29, (2011/02/24)
Compounds of formula (I) are inhibitors of Chk1, useful in the treatment of, inter alia, cancers: wherein R1, R2, R5 and R6 are independently selected from hydrogen, hydroxy, methyl, trifluoromethyl, hydroxy methyl, methoxy, trifluoromethoxy, methylamino and dimethylamino; R3, and R4 are independently selected from hydrogen, hydroxy, C1-C3 alkyl, fluoro-(C1-C3)-alkyl, hydroxy-(C1-C3)-alkyl, C1-C3 alkoxy, fluoro-(C1-C3)-alkoxy, hydroxy-(C1-C3)-alkoxy, -N(R11)-R12, -AIk-N(R11)-R12, -0-AIk-N(R11)-R12, -C(=O)OH, carboxy-(C1-C3)-alkyl, or -C(=O)-NH-R13; AIk is a straight or branched chain divalent C1-C6 alkylene radical; R7 and R8 are independently selected from hydrogen, hydroxy, or C1-C3 alkoxy; X is a straight chain divalent C1-C3 alkylene radical, optionally substituted on one or more carbons by R9 and/or R10; W is selected from -C(=O)-N(-R16)- or -N(-R17)-C(=O)-; Y is hydrogen, C1-C3 alkyl, C1-C3 alkoxy, or halo; and Q is an optionally substituted 5-membered monocyclic heteroaryl ring.
IDENTIFICATION OF COMPOUNDS SUITABLE FOR TREATING AD
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Page/Page column 14, (2008/06/13)
The invention provides a method of screening for compounds which inhibit the hyperphosphorylation of tau, and hence are suitable for treating AD and related conditions.
