33606-34-7

Basic information

• Product Name: 2-(tetrahydrofuran-2-yl)ethanol
• Synonyms: 2-(tetrahydrofuran-2-yl)ethanol;2-(OXOLAN-2-YL)ETHAN-1-OL(WXC08086);2-(TETRAHYDROFURAN-2-YL)ETHAN-1-OL;2-(tetrahydro-2-furanyl)ethanol
• CAS NO: 33606-34-7
• Molecular Formula: C₆H₁₂O₂
• Molecular Weight: 116.15828
• Mol File: 33606-34-7.mol
• Article Data: 13

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 2-(tetrahydrofuran-2-yl)ethanol(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(tetrahydrofuran-2-yl)ethanol(33606-34-7)
• EPA Substance Registry System: 2-(tetrahydrofuran-2-yl)ethanol(33606-34-7)

Safety Data

• Hazardous Substances Data: 33606-34-7(Hazardous Substances Data)

Usage

Physical state

Clear, colorless liquid

Odor

Slightly sweet

Flammability

Highly flammable

Uses

Solvent, production of polymers and resins, synthesis of pharmaceuticals, pharmaceutical intermediate

Safety precautions

Avoid contact with skin and eyes, may cause irritation and harm.

Upstream product

• 629-11-8 1,6-hexanediol 
• 126502-98-5 3-hydroxy-6-bromohexanoic acid 
• 2434-02-8 ethyl tetrahydrofuran-2-acetate 
• 123433-61-4 4-(3-Benzyloxy-propyl)-3-trimethylsilanyl-oxetan-2-one 
• 123433-56-7 4-(3-Benzyloxy-propyl)-oxetan-2-one 
• 123433-58-9 (Tetrahydro-furan-2-yl)-acetic acid benzyl ester 
• 35942-95-1 2-(furan-2-yl)ethanol 

Downstream Products

• 2434-00-6 (tetrahydro-furan-2-yl)-acetic acid 
• 1050493-67-8 2-(2-bromoethyl)oxolane 
• 895244-33-4 2-tetrahydrofuran-2-ylethyl 4-methylbenzenesulfonate 
• 888741-17-1 ethyl 3-[3-({[tert-butyl(diphenyl)silyl]oxy}methyl)-5-isopropoxyphenyl]propanoate 

Relevant articles and documents

PIKFYVE KINASE INHIBITORS

The present invention relates to compounds useful as inhibitors of phosphatidylinositol-3-phosphate 5-kinase (PIKfyve) as well as their use for treating diseases and disorders associated with PIKfyve.

An Intramolecular Iodine-Catalyzed C(sp3)?H Oxidation as a Versatile Tool for the Synthesis of Tetrahydrofurans

The formation of ubiquitous occurring tetrahydrofuran patterns has been extensively investigated in the 1960s as it was one of the first examples of a non-directed remote C?H activation. These approaches suffer from the use of toxic transition metals in overstoichiometric amounts. An attractive metal-free solution for transforming carbon-hydrogen bonds into carbon-oxygen bonds lies in applying economically and ecologically favorable iodine reagents. The presented method involves an intertwined catalytic cycle of a radical chain reaction and an iodine(I/III) redox couple by selectively activating a remote C(sp3)?H bond under visible-light irradiation. The reaction proceeds under mild reaction conditions, is operationally simple and tolerates many functional groups giving fast and easy access to different substituted tetrahydrofurans.

Sulfamyl Radicals Direct Photoredox-Mediated Giese Reactions at Unactivated C(3)-H Bonds

Alcohol-anchored sulfamate esters guide the alkylation of tertiary and secondary aliphatic C(3)-H bonds. The transformation proceeds directly from N-H bonds with a catalytic oxidant, a contrast to prior methods which have required preoxidation of the reactive nitrogen center, or employed stoichiometric amounts of strong oxidants to obtain the sulfamyl radical. These sulfamyl radicals template otherwise rare 1,6-hydrogen-atom transfer (HAT) processes via seven-membered ring transition states to enable C(3)-H functionalization during Giese reactions.