33667-80-0

Basic information

• Product Name: 2,4,6-TRIMETHYL DIPHENYL SULFIDE
• Synonyms: 2,4,6-TRIMETHYL DIPHENYL SULFIDE;Trimethyldiphenylsulfide;2,4,6-Trimethyl;2,4,6-TRIMETHYL DIPHENYL SULFIDE 97%MIN;mesityl(phenyl)sulfane;2,4,6-TRIMETHYL DIPH
• CAS NO: 33667-80-0
• Molecular Formula: C₁₅H₁₆S
• Molecular Weight: 228.35
• Mol File: 33667-80-0.mol
• Article Data: 28

Chemical Properties

• Boiling Point: 305.698 °C at 760 mmHg
• Flash Point: 128.935 °C
• Appearance: /
• Density: 1.075 g/cm³
• Vapor Pressure: 0.001mmHg at 25°C
• Refractive Index: 1.607
• CAS DataBase Reference: 2,4,6-TRIMETHYL DIPHENYL SULFIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4,6-TRIMETHYL DIPHENYL SULFIDE(33667-80-0)
• EPA Substance Registry System: 2,4,6-TRIMETHYL DIPHENYL SULFIDE(33667-80-0)

Safety Data

• Hazardous Substances Data: 33667-80-0(Hazardous Substances Data)

Usage

General Description

2,4,6-Trimethyl diphenyl sulfide is a chemical compound that belongs to the family of sulfides. It is a clear, colorless liquid with a strong odor and is commonly used as a solvent and as an intermediate in the production of various organic compounds. This chemical is also known for its ability to act as a reducing agent in organic synthesis. Additionally, it has potential applications in the pharmaceutical and agrochemical industries. However, 2,4,6-trimethyl diphenyl sulfide may pose health risks if not handled properly, as it is toxic and can cause skin and eye irritation. It is important to follow proper safety precautions when working with this chemical.

InChI:InChI=1/C15H16S/c1-11-9-12(2)15(13(3)10-11)16-14-7-5-4-6-8-14/h4-10H,1-3H3

Upstream product

• 42157-57-3 2-(ethylsulfanyl)-1,3,5-trimethylbenzene 
• 118-92-3 anthranilic acid 
• 576-83-0 2,4,6-trimethylphenyl bromide 
• 108-98-5 thiophenol 
• 3541-14-8 phenyl toluene-4-thiosulfonate 
• 108-67-8 1,3,5-trimethyl-benzene 
• 14204-27-4 N-phenylthiophthalimide 
• 14204-24-1 N-(phenylthio)succinimide 
• 136918-14-4 phthalimide 
• 5980-97-2 mesitylboronic acid 
• 931-59-9 benzenesulfenyl chloride 
• 773-64-8 2-mesitylenesulphonyl chloride 
• 1541-10-2 mesitylthiol 
• 62-53-3 aniline 

Downstream Products

• 3112-82-1 (2,4,6-trimethylphenyl) phenyl sulfone 

Relevant articles and documents

Chan-Lam-Type C-S Coupling Reaction by Sodium Aryl Sulfinates and Organoboron Compounds

A Chan-Lam-Type C-S coupling reaction using sodium aryl sulfinates has been developed to provide diaryl thioethers in up to 92% yields in the presence of a copper catalyst and potassium sulfite. Both electron-rich and electron-poor sodium aryl sulfinates and diverse organoboron compounds were tolerated for the synthesis of aryl and heteroaryl thioethers and dithioethers. The mechanistic study suggested that potassium sulfite was involved in the deoxygenation of sulfinate through a radical process.

A Robust Pd-Catalyzed C-S Cross-Coupling Process Enabled by Ball-Milling

An operationally simple mechanochemical C-S coupling of aryl halides with thiols has been developed. The reaction process operates under benchtop conditions without the requirement for a (dry) solvent, an inert atmosphere, or catalyst preactivation. The reaction is finished within 3 h. The reaction is demonstrated across a broad range of substrates; the inclusion of zinc metal has been found to be critical in some instances, especially for coupling of alkyl thiols.

Iodine(III) Enabled Dehydrogenative Aryl C?S Coupling by in situ Generated Sulfenium Ion

Due to the normal polarity preferences, arenes form stable complexes with thiols through S?H???π interaction and direct dehydrogenative aryl C?S coupling is usually restricted. We report here an umpolung based one pot and direct C?S coupling approach unde