33683-44-2Relevant articles and documents
Catalytic enantioselective peroxidation of α,β-unsaturated ketones
Lu, Xiaojie,Liu, Yan,Sun, Bingfeng,Cindric, Brittany,Deng, Li
supporting information; body text, p. 8134 - 8135 (2009/02/02)
Despite the potential of chiral peroxides as biologically interesting or even clinically important compounds, no catalytic enantioselective peroxidation has been reported. With a chiral catalyst not only to induce enantioselectivity but also to convert a well established epoxidation pathway into a peroxidation pathway, the first efficient catalytic peroxidation has been successfully developed. Employing readily available α,β-unsaturated ketones and hydroperoxides and an easily accessible cinchona alkaloid catalyst, this novel reaction will open new possibilities in the asymmetric synthesis of chiral peroxides. Under different conditions a highly enantioselective epoxidation with the same starting materials, reagents, and catalyst has was also established. Copyright
