33781-38-3

Basic information

• Product Name: 5-CHLORO-2,3-DIHYDRO-1H-INDEN-1-OL
• Synonyms: 5-CHLORO-2,3-DIHYDRO-1H-INDEN-1-OL
• CAS NO: 33781-38-3
• Molecular Formula: C₉H₉ClO
• Molecular Weight: 168.62
• Mol File: 33781-38-3.mol
• Article Data: 14

Chemical Properties

• Appearance: /
• Storage Temp.: Sealed in dry,Room Temperature
• CAS DataBase Reference: 5-CHLORO-2,3-DIHYDRO-1H-INDEN-1-OL(CAS DataBase Reference)
• NIST Chemistry Reference: 5-CHLORO-2,3-DIHYDRO-1H-INDEN-1-OL(33781-38-3)
• EPA Substance Registry System: 5-CHLORO-2,3-DIHYDRO-1H-INDEN-1-OL(33781-38-3)

Safety Data

• Hazardous Substances Data: 33781-38-3(Hazardous Substances Data)

Usage

General Description

5-CHLORO-2,3-DIHYDRO-1H-INDEN-1-OL is a chemical compound with the molecular formula C9H9ClO. It is a chlorinated derivative of 2,3-dihydro-1H-inden-1-ol, and it is commonly used in the synthesis of pharmaceuticals and agrochemicals. 5-CHLORO-2,3-DIHYDRO-1H-INDEN-1-OL is known for its potential use as a building block in organic synthesis, as well as its ability to act as a chiral ligand in asymmetric synthesis. It is also used in the production of fragrances and flavors. The compound has a slightly yellow appearance and is typically handled and stored in a cool, dry place away from direct sunlight and sources of ignition. Overall, 5-CHLORO-2,3-DIHYDRO-1H-INDEN-1-OL is a versatile chemical with a range of potential applications in various industries.

Upstream product

• 42348-86-7 5-chloro-1-indanone 
• 3946-29-0 3,4'-Dichloropropiophenone 
• 108-90-7 chlorobenzene 

Downstream Products

• 3970-52-3 6-chloro-1H-indene 
• 192702-71-9 1-bromo-5-chloroindane 
• 42348-86-7 5-chloro-1-indanone 
• 62882-02-4 6-chloroisoquinoline 
• 1294452-94-0 ethyl 3-(4-(5-chloro-2,3-dihydro-1H-inden-1-yloxy)phenyl)propiolate 
• 1312788-42-3 C₁₈H₁₃ClO₃ 
• 1330776-76-5 2-hydroxy-5,5-dimethyl-2-(3-oxo-1,3-diphenylpropyl)cyclohexane-1,3-dione 

Relevant articles and documents

ATF6 MODULATORS AND USES THEREOF

Compounds (I) as modulators of Activating Transcription Factor 6 (ATF6) are provided. The compounds may find use as therapeutic agents for the treatment of diseases or disorders mediated by ATF6 and may find particular use in the treatment of viral infections, neurodegenerative diseases, vascular diseases, or cancer.

Silylative Kinetic Resolution of Racemic 1-Indanol Derivatives Catalyzed by Chiral Guanidine

Efficient kinetic resolution of racemic 1-indanol derivatives was achieved using triphenylchlorosilane by asymmetric silylation in the presence of chiral guanidine catalysts. The chiral guanidine catalyst (R,R)-N-(1-(β-naphthyl)ethyl)benzoguanidine was found to be highly efficient as only 0.5 mol % catalyst loading was sufficient to catalyze the reaction of various substrates with appropriate conversion and high s-values (up to 89). This catalyst system was successfully applied to the gram-scale silylative kinetic resolution of racemic 1-indanol with high selectivity.

Synthesis of Indole-Dihydroisoquinoline Sulfonyl Ureas via Three-Component Reactions

Isoquinolines activated with sulfamoyl chlorides were reacted with indoles in a 3-component reaction to generate a library of dihydroisoquinoline derivatives. Using a differential protecting group strategy, products could be further derivatised. Synthesis of isoquinoline starting materials using several different methods is also described.