337958-60-8

Basic information

• Product Name: 5,7-dichloro-1,6-naphthyridine
• Synonyms: 5,7-dichloro-1,6-naphthyridine;1,6-Naphthyridine,5,7-dichloro-
• CAS NO: 337958-60-8
• Molecular Formula: C₈H₄Cl₂N₂
• Molecular Weight: 199.04
• EINECS: 1533716-785-6
• Product Categories: CHIRAL CHEMICALS
• Mol File: 337958-60-8.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 344.503 °C at 760 mmHg
• Flash Point: 192.885 °C
• Appearance: White to yellow/Crystalline Powder
• Density: 1.487 g/cm³
• Refractive Index: 1.671
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• PKA: 0.82±0.30(Predicted)
• CAS DataBase Reference: 5,7-dichloro-1,6-naphthyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 5,7-dichloro-1,6-naphthyridine(337958-60-8)
• EPA Substance Registry System: 5,7-dichloro-1,6-naphthyridine(337958-60-8)

Safety Data

• Hazardous Substances Data: 337958-60-8(Hazardous Substances Data)

Usage

General Description

5,7-dichloro-1,6-naphthyridine is a heterocyclic compound with a naphthyridine core structure, containing two chlorine atoms at the 5th and 7th positions. It is commonly used as a building block in the synthesis of pharmaceuticals, agrochemicals, and other organic compounds. This chemical is known for its potent biological activities, including antibacterial, antifungal, and antitumor properties. Its versatile nature and reactivity make it a valuable intermediate in organic synthesis and medicinal chemistry, with potential applications in drug discovery and development. However, it is important to handle 5,7-dichloro-1,6-naphthyridine with caution as it is a hazardous chemical that can cause irritation to the skin, eyes, and respiratory system.

InChI:InChI=1/C8H4Cl2N2/c9-7-4-6-5(8(10)12-7)2-1-3-11-6/h1-4H

Upstream product

• 2587-02-2 2,6-dichloro-[4]pyridylamine 
• 2942-59-8 2-chloronicotinic acid 
• 927-63-9 (E)-3-(dimethylamino)acrolein 
• 1345456-45-2 N-(2,6-dichloro-4-pyridinyl)-2,2-dimethylpropanamide 
• 1345461-33-7 1,6-naphthyridin-5,7(6H,8H)-dione 

Downstream Products

• 1400679-83-5 7-(3,5-dimethylphenyl)-5-(2,3,4-trimethoxyphenyl)-1,6-naphthyridine 
• 1400679-84-6 7-(p-tolyl)-5-(2,3,4-trimethoxyphenyl)-1,6-naphthyridine 
• 1400679-85-7 7-(4-tert-butylphenyl)-5-(2,3,4-trimethoxyphenyl)-1,6-naphthyridine 
• 1400679-65-3 7-chloro-5-(4-fluorophenyl)-1,6-naphthyridine 
• 1400679-68-6 7-chloro-5-(o-tolyl)-1,6-naphthyridine 
• 1400679-62-0 7-chloro-5-(p-tolyl)-1,6-naphthyridine 
• 1400679-75-5 5,7-di(p-tolyl)-1,6-naphthyridine 
• 1400679-69-7 7-chloro-5-(4-chlorophenyl)-1,6-naphthyridine 
• 1400679-71-1 7-chloro-5-(4-methoxyphenyl)-1,6-naphthyridine 
• 1400679-82-4 5,7-bis(4-methoxyphenyl)-1,6-naphthyridine 
• 1400679-81-3 5,7-bis(3-fluorophenyl)-1,6-naphthyridine 
• 1400679-72-2 7-chloro-5-(4-ethylphenyl)-1,6-naphthyridine 
• 1400679-77-7 5,7-bis(4-ethylphenyl)-1,6-naphthyridine 
• 1400679-64-2 7-chloro-5-(2-methoxyphenyl)-1,6-naphthyridine 

Relevant articles and documents

7-(lH-PYRAZOL-4-YL)-1,6-NAPHTHYRIDINE COMPOUNDS AS SYK INHIBITORS

The present invention relates to a compound of formula (I): or a salt thereof; which is an inhibitor of spleen tyrosine kinase (Syk) and therefore potentially of use in treating diseases resulting from inappropriate activation of mast and/or basophil cells, macrophages, and B-cells and related inflammatory responses and tissue damage, for instance inflammatory disease and/or allergic disorders, and in cancer therapy, specifically heme malignancies, chronic spontaneous urticaria and autoimmune conditions.