338454-02-7

Basic information

• Product Name: methyl 3,5-dihydroxy-4-iodobenzoate
• Synonyms: methyl 3,5-dihydroxy-4-iodobenzoate;3,5-Dihydroxy-4-iodo-benzoic acid methyl ester
• CAS NO: 338454-02-7
• Molecular Formula: C₈H₇IO₄
• Molecular Weight: 294.04325
• Mol File: 338454-02-7.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 330℃
• Flash Point: 153℃
• Appearance: /
• Density: 2.010
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.671
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• CAS DataBase Reference: methyl 3,5-dihydroxy-4-iodobenzoate(CAS DataBase Reference)
• NIST Chemistry Reference: methyl 3,5-dihydroxy-4-iodobenzoate(338454-02-7)
• EPA Substance Registry System: methyl 3,5-dihydroxy-4-iodobenzoate(338454-02-7)

Safety Data

• Hazardous Substances Data: 338454-02-7(Hazardous Substances Data)

Usage

General Description

Methyl 3,5-dihydroxy-4-iodobenzoate is a chemical compound recognized for its specific organic structure. It prominently features an iodine atom, two hydroxyl (OH) groups, and a methyl ester group attached to a benzene ring, the primary component in its structure. The presence of hydroxyl groups gives this compound some polar properties, while the iodine atom adds significant molecular weight. methyl 3,5-dihydroxy-4-iodobenzoate resides within the realm of organic chemistry and is specifically known as a derivative of benzoic acid due to its carboxyl group that has been converted into a methyl ester. This chemical might have potential uses in the synthesis of more complex molecules in the field of medicinal chemistry or materials science, but its specific applications would depend on further scientific exploration.

InChI:InChI=1/C8H7IO4/c1-13-8(12)4-2-5(10)7(9)6(11)3-4/h2-3,10-11H,1H3

Upstream product

• 99-10-5 3,5-Dihydroxybenzoic acid 
• 2150-44-9 1-carbomethoxy-3,5-dihydroxybenzene 

Downstream Products

• 338455-12-2 3-benzyloxy-5-hydroxy-4-iodo-benzoic acid methyl ester 
• 338454-03-8 3,5-Diethoxy-4-iodo-benzoic acid methyl ester 
• 1202878-17-8 2-(cyclohex-1-enyl)-4-hydroxy-6-(methoxycarbonyl)benzofuran 
• 1202878-21-4 2-[3-(tert-butyldiphenylsiloxy)propyl]-4-hydroxy-6-(methmethoxycarbonyl)benzofuran 
• 1202878-16-7 4-hydroxy-6-methoxycarbonyl-2-phenylbenzofuran 
• 314725-17-2 methyl 4-hydroxy-2-methylbenzofuran-6-carboxylate 

Relevant articles and documents

HETEROCYCLIC PAD4 INHIBITORS

The disclosure generally relates to substituted heterocyclic compounds of Formula (Ia), which are inhibitors of PAD4, method for preparing these compounds, pharmaceutical compositions comprising these compounds and use of these compounds in the treatment of a disease or a disorder associated with PAD4 enzyme activity.

Total Synthesis of Isohericenone J via a Stille Coupling Reaction

The first total synthesis of isohericenone J is reported. Key features of this synthetic strategy are a Friedel-Crafts reaction to construct the isobenzofuranone unit and a Pd-catalyzed Stille coupling reaction for the formation of the C5-C1′ bond, generating the natural product, as well as one of its isomers, in 6.0% overall yield in eight steps. This strategy provides a foundation for the synthesis of challenging isobenzofuranone and isoindolinone-type derivatives.

Enantioselective Electrochemical Lactonization Using Chiral Iodoarenes as Mediators

The enantioselective electrochemical lactonization of diketo acid derivatives using chiral iodoarenes as redox mediators is reported for the first time. Good to high stereoselectivities are observed in the lactonization and also in intermolecular α-alkoxylations of diketo ester derivatives. This enantioselective process was then adapted to an electrochemical flow microreactor where only small amounts of supporting electrolyte were necessary.