338454-45-8

Basic information

• Product Name: 5-Hydroxymethylthiophene-2-boronic acid
• Synonyms: 5-HYDROXYMETHYLTHIOPHENE-2-BORONIC ACID;[5-(hydroxyMethyl)thiophen-2-yl]boronic acid;5-(hydroxymethyl)thiophen-2-yl-2-boronic acid;5-Hydroxymethylthiophene-2-boronic acid, >=98%;5-(Hydroxymethyl)thiophene-2-boronic aicd
• CAS NO: 338454-45-8
• Molecular Formula: C₅H₇BO₃S
• Molecular Weight: 157.98
• Product Categories: Boronic Acid
• Mol File: 338454-45-8.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 399.9 °C at 760 mmHg
• Flash Point: 195.6 °C
• Appearance: /
• Density: 1.42 g/cm³
• Vapor Pressure: 4.12E-07mmHg at 25°C
• Refractive Index: 1.594
• Storage Temp.: Keep in dark place,Inert atmosphere,Store in freezer, under -20°C
• PKA: 8.42±0.53(Predicted)
• CAS DataBase Reference: 5-Hydroxymethylthiophene-2-boronic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 5-Hydroxymethylthiophene-2-boronic acid(338454-45-8)
• EPA Substance Registry System: 5-Hydroxymethylthiophene-2-boronic acid(338454-45-8)

Safety Data

• Hazardous Substances Data: 338454-45-8(Hazardous Substances Data)

Usage

General Description

5-Hydroxymethylthiophene-2-boronic acid is a chemical compound often used in scientific and pharmaceutical research. It comes in the form of a yellowish-white powder and is known for its role in palladium-catalyzed cross-coupling reactions - a process often used in pharmaceutical chemistry to create complex molecules. 5-Hydroxymethylthiophene-2-boronic acid is known for its stability under normal temperatures and pressures, but can decompose when heated. When handled, it should be stored in a tightly closed container in a cool, dry, well-ventilated location. It is water soluble and poses minimal hazard to humans and the environment if handled appropriately. It can be hazardous if it comes in contact with skin or eyes, or if ingested or inhaled.

InChI:InChI=1/C5H7BO3S/c7-3-4-1-2-5(10-4)6(8)9/h1-2,7-9H,3H2

Upstream product

• 636-72-6 2-thiophenemethanol 

Downstream Products

• 1142945-85-4 (5-{2-[4-(2-pyrrolidin-1-yl-ethoxy)-phenylamino]-7H-pyrrolo[2,3-d]pyrimidin-4-yl}-thiophen-2-yl)-methanol 
• 1220972-77-9 4-[5-(hydroxymethyl)thiophen-2-yl]benzaldehyde 

Relevant articles and documents

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Substituted 5-benzyl-2,4-diaminopyrimidines

The invention relates to substituted 5-benzyl-2,4-diaminopyrimidines of general formula (A) wherein R1is C2-C3 alkyl an R2is heterocyclyl, phenyl or naphthyl, bonded by one of its C-atoms and R3is C2-C6 alkyl, alkenyl, cycloalkyl, cycloalkylalkyl, heterocyclylalkyl, alkylsulfonyl, cycloalkylsulfonyl, cycloalkylalkylsulfamoyl, heterocyclysylfonyl, heterocyclylalkylsulfonyl or dialkylsulfamoyl; wherein alkyl, cycloalkyl and alyenyl can carry up to 6 carbon atoms alone or in compositions and can carry up to 6 ring members heterocyclically, alone, or in compositions and the groups R2and R3can be substituted; and to acid addition salts of compounds. The invention also relates to a method for producing the above 5-benzyl-2,4-diaminopyrimidines, to the intermediate. products that are produced, to corresponding medicaments and to the use of 5-benzyl-2,4-diaminopyrimidines as medicinal preparations. The products have antibiotic properties and are useful for combating or preventing infectious diseases.