33866-44-3 Usage
Description
3-(2-FURYL)ISOXAZOL-5-AMINE is a chemical compound that belongs to the class of isoxazoles, which are five-membered heterocyclic compounds that contain an oxygen and a nitrogen atom in the ring. This specific compound contains a furan ring (a five-membered aromatic ring with four carbon atoms and one oxygen atom) attached to the isoxazole ring. It has potential applications in medicinal and pharmaceutical research due to its interesting structural features and potential biological activities.
Uses
Used in Medicinal and Pharmaceutical Research:
3-(2-FURYL)ISOXAZOL-5-AMINE is used as a drug candidate for the treatment of various diseases and conditions. Its unique structural features and potential biological activities make it a promising candidate for further research and development in the pharmaceutical industry.
Used in Scientific Research:
3-(2-FURYL)ISOXAZOL-5-AMINE is used as a subject of study for its synthesis and properties. Understanding the compound's characteristics can provide valuable insights into its potential applications and effectiveness in treating specific diseases and conditions.
Check Digit Verification of cas no
The CAS Registry Mumber 33866-44-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,3,8,6 and 6 respectively; the second part has 2 digits, 4 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 33866-44:
(7*3)+(6*3)+(5*8)+(4*6)+(3*6)+(2*4)+(1*4)=133
133 % 10 = 3
So 33866-44-3 is a valid CAS Registry Number.
InChI:InChI=1/C7H6N2O2/c8-7-4-5(9-11-7)6-2-1-3-10-6/h1-4H,8H2
33866-44-3Relevant articles and documents
An enantioselective aza-Friedel-Crafts reaction of 5-aminoisoxazoles with isatin-derived: N -Boc ketimines
Liu, Hui,Yan, Yingkun,Li, Min,Zhang, Xiaomei
supporting information, p. 3820 - 3824 (2021/05/14)
By employing a chiral phosphoric acid as a catalyst, an enantioselective aza-Friedel-Crafts reaction of 5-aminoisoxazoles with isatin-derived N-Boc ketimines was realized. The reaction provided a wide variety of novel 3-isoxazole 3-amino-oxindoles with good yields (up to 99%) and moderate to good enantioselectivities (up to 99%). The absolute configuration of one product was assigned by X-ray crystal structural analysis and a plausible reaction mechanism was proposed. In addition, a scale-up reaction was performed successfully. Finally, one product was subjected to Suzuki-Miyaura coupling with phenylboronic acid to afford the product in a moderate yield without erosion of the enantioselectivity. This journal is
Hoveyda-Grubbs II Catalyst: A Useful Catalyst for One-Pot Visible-Light-Promoted Ring Contraction and Olefin Metathesis Reactions
Ge, Yun,Sun, Wangbin,Pei, Bingbing,Ding, Jia,Jiang, Yaojia,Loh, Teck-Peng
supporting information, p. 2774 - 2777 (2018/05/22)
A one-pot reaction to synthesize functionalized 2H-azirines through visible-light-mediated ring contraction and olefin metathesis of isoxazoles is described. Hoveyda-Grubbs II catalyst was found to function as a photocatalyst for these transformations, al