33878-70-5

Basic information

• Product Name: (S)-5-(Pyrrolidin-2-yl)-1H-tetrazole
• Synonyms: (S)-5-(Pyrrolidin-2-yl)-1H-tetrazole;(S)-(-)-2-Tetrazol-5-ylpyrrolidine, Proline Tetrazole Catalyst;(S)-(-)-5-(2-Pyrrolidinyl)-1H-tetrazole;(S)-(–)-5-(2-Pyrrolidinyl)-1H-tetrazole 96%;(S)-(-)-5-(2-Pyrolidinyl)-1H-tetrazole;1H-Tetrazole, 5-(2S)-2-pyrrolidinyl-;(S)-2-(1H-Tetrazol-5-yl)pyrrolidine;(S)-2-Tetrazol-5-ylpyrrolidine
• CAS NO: 33878-70-5
• Molecular Formula: C₅H₉N₅
• Molecular Weight: 139.16
• Product Categories: Asymmetric Synthesis;Synthetic Organic Chemistry
• Mol File: 33878-70-5.mol
• Article Data: 0

Chemical Properties

• Melting Point: 271 °C
• Boiling Point: 335.37°C at 760 mmHg
• Flash Point: 156.626°C
• Appearance: /
• Density: 1.301g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: -8 ° (C=1, MeOH)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 3.77±0.10(Predicted)
• CAS DataBase Reference: (S)-5-(Pyrrolidin-2-yl)-1H-tetrazole(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-5-(Pyrrolidin-2-yl)-1H-tetrazole(33878-70-5)
• EPA Substance Registry System: (S)-5-(Pyrrolidin-2-yl)-1H-tetrazole(33878-70-5)

Safety Data

• Hazard Codes: T
• Statements: 25-36/37/38
• Safety Statements: 26-36/37-45
• RIDADR: UN 2811 6.1/PG 3
• WGK Germany: 3
• Hazardous Substances Data: 33878-70-5(Hazardous Substances Data)

Usage

Chemical Properties

Colorless solid

Uses

Organocatalyst used for:Direct asymmetric aldol reactions between acetone and aldehydes yielding β -hydroxy ketone and for synthesizing 1,1,1-trichloro-2-alkanolsMannich reactions for synthesis fo α -amino acids and generation of 1,4-diaminesConjugate additions of malonates to enones

InChI:InChI=1/C5H9N5/c1-2-4(6-3-1)5-7-9-10-8-5/h4,6H,1-3H2,(H,7,8,9,10)/t4-/m0/s1

Downstream Products

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• 917963-20-3 (Z,6R,10aS)-5-(4-N,N-diethylaminophenyl)imino-6-iso-butyl-8,9,10,10a-tetrahydro-6H-tetrazolo[1,5-a]pyrrolo[2,1-c]pyrazine 
• 1210262-32-0 (S)-5-[1-(2-bromobenzyl)pyrrolidin-2-yl]-1H-tetrazole 
• 1616724-03-8 (S)-N-((1R,1'R,3r,3'R,5S,5'S)-[3,9'-bi(9'-azabicyclo[3.3.1]nonan)]-3'-yl)-N-phenyl-2-(1H-tetrazol-5-yl)pyrrolidine-1-carboxamide 
• 33876-20-9 (2S)-2-(1H-tetrazol-5-yl)-pyrrolidine-1-carboxylic acid benzyl ester 
• 96792-03-9 5-<1-<5(S)-benzamido-4-oxo-6-phenylhexanoyl>pyrrolidin-2-yl>tetrazole