33953-86-5

Basic information

• Product Name: 2,2,2-TRIFLUOROACETALDEHYDE HYDRATE
• Synonyms: Trifluoracetaldehyde Monohydrate;2,2,2-Trifluoro-1,1-ethanediol, Fluoral hydrate;Trifluoroacetaldehyde monohydrate, 72% aqueous solution;2,2,2-Trifluoroacetaldehyde (72% in aqueous solution) Monohydrate;TRIFLUOROACETALDEHYDE HYDRATE, 72% aqueous solution;Trifluoroacetaldehyde Monohydrate (ca. 75% in Water);Trifluoracetaldehyde monohydrate technical, ~75% in H2O;Acetaldehyde,2,2,2-trifluoro-, hydrate (1:1)
• CAS NO: 33953-86-5
• Molecular Formula: C2H3F3O2
• Molecular Weight: 116.0392296
• EINECS: 207-006-4
• Mol File: 33953-86-5.mol
• Article Data: 4

Chemical Properties

• Melting Point: 93-94℃
• Boiling Point: 104-106 °C(lit.)
• Flash Point: -23 °C
• Appearance: /
• Density: 1.44 g/mL at 20 °C(lit.)
• Refractive Index: n20/D 1.340
• CAS DataBase Reference: 2,2,2-TRIFLUOROACETALDEHYDE HYDRATE(CAS DataBase Reference)
• NIST Chemistry Reference: 2,2,2-TRIFLUOROACETALDEHYDE HYDRATE(33953-86-5)
• EPA Substance Registry System: 2,2,2-TRIFLUOROACETALDEHYDE HYDRATE(33953-86-5)

Safety Data

• Hazard Codes: F,Xn
• Statements: 11-22-37/38-41-43-36
• Safety Statements: 26-39-36/37-16
• RIDADR: UN 1989 3/PG 2
• WGK Germany: 3
• Hazardous Substances Data: 33953-86-5(Hazardous Substances Data)

Usage

General Description

2,2,2-Trifluoroacetaldehyde hydrate is a chemical compound with the formula CF3CHO that exists as a colorless liquid. It is used in the synthesis of various pharmaceuticals and agrochemicals and as a solvent in organic reactions. The compound is also utilized in the production of fluorine-containing polymers and as an intermediate in the manufacturing of other fluorinated compounds. Additionally, 2,2,2-Trifluoroacetaldehyde hydrate is used as a building block for the preparation of specialty chemicals and can be found in some research and development applications. It is important to handle this chemical with caution as it may cause irritation to the skin, eyes, and respiratory tract, and prolonged exposure can be harmful.

Upstream product

• 75-46-7 trifluoromethan 
• 383-63-1 ethyl trifluoroacetate, 
• 75-89-8 2,2,2-trifluoroethanol 
• 420-46-2 2,2,2-trifluoroethanol 

Downstream Products

• 86884-21-1 rac-4,4,4-trifluoro-3-hydroxybutanoic acid 

Relevant articles and documents

Process for preparing trifluoroacetaldehyde hydrate from 1,1,1-halothane

The invention discloses a process for preparing trifluoroacetaldehyde hydrate from 1,1,1-halothane. The process comprises the following steps of preheating a raw material mixture consisting of 1,1,1-halothane, oxygen gas and nitrogen gas; then, injecting the mixture into a fixed bed reactor; using Fe2O3/AlF3 or CuO/AlF3 as a catalyst; performing reaction at 0.1 to 3 mPa at 100 to 500 DEG C, wherein the reaction is continuously performed; adsorbing products at an outlet; and separating out the trifluoroacetaldehyde hydrate. The process for preparing the trifluoroacetaldehyde hydrate provided by the invention has the advantages that the conversion rate of the 1,1,1-halothane can reach 16 to 39 percent; the selectivity of the trifluoroacetaldehyde hydrate can reach 20 percent or higher; through the process, the 1,1,1-halothane can be directly converted into the trifluoroacetaldehyde hydrate; the reaction process is simple; the product can be easily separated; the purity of the obtained trifluoroacetaldehyde hydrate can reach 95 percent or higher. The trifluoroacetaldehyde hydrate capable of being applied to important chemical products can be prepared and produced at high efficiency and low cost.

Perfluoroalkylation method and reagent therefor

PCT No. PCT/FR96/01854 Sec. 371 Date Feb. 22, 1999 Sec. 102(e) Date Feb. 22, 1999 PCT Filed Nov. 22, 1996 PCT Pub. No. WO97/19038 PCT Pub. Date May 29, 1997The subject-matter of the present invention is a process of use in perfluoroalkylation and a reactant for making use of this process. This process is defined in that it comprises a stage in which a material of formula RfH and a base (or a species capable of generating a base) are brought into contact, in a polar and anhydrous medium, with a substrate carrying at least one electrophilic functional group. Application to organic synthesis.