3399-22-2

Basic information

• Product Name: DIMETHYL TRANS-1,4-CYCLOHEXANEDICARBOXYLATE
• Synonyms: TRANS-1,4-DIMETHYL CYCLOHEXANEDICARBOXYLATE;4-Cyclohexanedicarboxylicacid,dimethylester,trans-1;dimethylester,trans-4-cyclohexanedicarboxylicacid;DIMETHYL TRANS-1,4-CYCLOHEXANEDICARBOXYLATE;DIMETHYL TRANS-CYCLOHEXANE-1,4-DICARBO-X YLATE;Dimethyl trans-1,4-cyclohexanedicarboxylate, 99+%;Dimethyl trans-1,4-Cyclohexanediarboxylate;(1r,4r)-dimethyl cyclohexane-1,4-dicarboxylate
• CAS NO: 3399-22-2
• Molecular Formula: C₁₀H₁₆O₄
• Molecular Weight: 200.23
• Product Categories: C10 to C11;Carbonyl Compounds;Esters;Building Blocks;C10 to C11;Carbonyl Compounds;Chemical Synthesis;Organic Building Blocks
• Mol File: 3399-22-2.mol
• Article Data: 11

Chemical Properties

• Melting Point: 67-69 °C(lit.)
• Boiling Point: 263.5±0.0℃ (760 Torr)
• Flash Point: 115.4±18.8℃
• Appearance: White to faintly yellow/Crystalline Powder
• Density: 1.102±0.06 g/cm3 (20 ºC 760 Torr)
• Refractive Index: 1.4560 (589.3 nm 31℃)
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: soluble in Methanol
• BRN: 2213375
• CAS DataBase Reference: DIMETHYL TRANS-1,4-CYCLOHEXANEDICARBOXYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: DIMETHYL TRANS-1,4-CYCLOHEXANEDICARBOXYLATE(3399-22-2)
• EPA Substance Registry System: DIMETHYL TRANS-1,4-CYCLOHEXANEDICARBOXYLATE(3399-22-2)

Safety Data

• Hazard Codes: Xi
• Statements: 52/53-38
• Safety Statements: 22-24/25-61-37
• WGK Germany: 3
• TSCA: Yes
• Hazardous Substances Data: 3399-22-2(Hazardous Substances Data)

Usage

Chemical Properties

White to faintly yellow crystalline powder

Upstream product

• 67-56-1 methanol 
• 619-82-9 trans-hexahydroterephthalic acid 
• 94-60-0 dimethyl 1,4-cyclohexane dicarboxylate 
• 15177-67-0 trans-4-(methoxycarbonyl)cyclohexanecarboxylic acid 
• 1165952-91-9 cyclohexa-1,3-diene 
• 13170-66-6 trans-1,4-cyclohexanedicarboxylic acid dichloride 
• 120-61-6 1,4-benzenedicarboxylic acid dimethyl ester 
• 74-88-4 methyl iodide 
• 186581-53-3 diazomethane 
• 3919-11-7 trans-Cyclohex-2-ene-1,4-dicarboxylic acid 
• 7647-01-0 hydrogenchloride 
• 64-19-7 acetic acid 
• 79368-45-9 7-Oxobicyclo<2.2.1>heptan-1-carbonylchlorid 
• 149-73-5 trimethyl orthoformate 

Downstream Products

• 16200-85-4 trans-4,4'-dicyclohexyldicarboxylic acid 
• 16200-84-3 trans,trans-4',4-bicyclohexanedicarboxylic acid dimethyl ester 
• 1467-84-1 ((1R,4R)-4-aminocyclohexyl)methanol 
• 1256276-45-5 benzyl (trans-4-(hydroxymethyl)cyclohexyl)carbamate 
• 619-82-9 trans-hexahydroterephthalic acid 
• 15177-67-0 trans-4-(methoxycarbonyl)cyclohexanecarboxylic acid 
• 3236-48-4 trans-1,4-Cyclohexanedimethanol 
• 3236-47-3 (1s,4s)-cyclohexane-1,4-diyldimethanol 
• 1260885-17-3 trans-4-[4-(3-trifluoromethyl-phenyl)-1H-imidazol-2-yl]-cyclohexyl-carboxylic acid 

Relevant articles and documents

DEOXYNOJIRIMYCIN DERIVATIVES AS GLUCOSIDASE INHIBITORS

The present invention relates to novel iminosugars and their use as glucosidase inhibitors. The present inventors discovered that certain deoxynojirimycin derivatives may be effective in inhibiting glucosidases. In particular, such deoxynojirimycin derivatives may be useful for treating a disease or condition in which inhibition of glucosidase may play an important role.

Preparation method of trans-1,4-cyclohexane dicarboxylic acid monomethyl ester

The invention discloses a preparation method of trans-1,4-cyclohexanedicarboxylic acid monomethyl ester. The preparation method comprises the following steps of using cis and trans mixed type dimethyl1,4-cyclohexanedicarboxylate with better solvent property in organic solvents as the raw material, performing isomerization reaction under the catalyzing action of an organic alkaline catalyst, and performing high-selectivity monoester hydrolyzing under the action of inorganic alkaline, so as to obtain the trans-1,4-cyclohexanedicarboxylic acid monomethyl ester. Compared with the prior art, the preparation method has the advantages that (1) the used raw material has good dissolvability in the organic solvent, such as methyl alcohol; (2) by adopting the optimized catalyst, the activating energy of the isomerization reaction is reduced, the isomerization time is shortened, the reaction energy consumption is decreased, the cost is reduced, and the optimized catalyst is suitable for industrialized production; (3) the hydrolyzing of diester is effectively reduced, the amount of diacid byproducts is reduced to be 2% or lower, and the product purity is improved; (4) a small amount of unreacted raw material is sent into an organic phase via an extracting procedure, and is separated from the product at high efficiency, so that the purity of the product is further improved.

TRICYCLIC PYRROLOPYRIDINE COMPOUND, AND JAK INHIBITOR

To provide a novel tricyclic pyrrolopyridine compound having a JAK inhibitory activity and useful for prevention, treatment and/or improvement of particularly autoimmune diseases, inflammatory diseases and allergic diseases. A novel tricyclic pyrrolopyridine compound represented by the formula (I), a tautomer or pharmaceutically acceptable salt of the compound or a solvate thereof: wherein the respective substituents are defined in detail in the specification, and R1 is a C1-6 alkyl group or the like, R2 is a hydrogen atom or the like, R3 is a hydrogen atom or the like, the ring A is C3-11 cycloalkane or the like, L1 is a C1-6 alkylene group or the like, and R4 is NRaRb or the like.