34025-59-7

Basic information

• Product Name: 2,4-bis(2-chlorophenyl)-3-azabicyclo[3.3.1]nonan-9-one
• CAS NO: 34025-59-7
• Molecular Formula: C₂₀H₁₉Cl₂NO
• Molecular Weight: 360.277
• Mol File: 34025-59-7.mol
• Article Data: 9

Chemical Properties

• Boiling Point: 479.7°C at 760 mmHg
• Flash Point: 243.9°C
• Density: 1.261g/cm³
• Vapor Pressure: 2.32E-09mmHg at 25°C
• Refractive Index: 1.595
• CAS DataBase Reference: 2,4-bis(2-chlorophenyl)-3-azabicyclo[3.3.1]nonan-9-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2,4-bis(2-chlorophenyl)-3-azabicyclo[3.3.1]nonan-9-one(34025-59-7)
• EPA Substance Registry System: 2,4-bis(2-chlorophenyl)-3-azabicyclo[3.3.1]nonan-9-one(34025-59-7)

Safety Data

• Hazardous Substances Data: 34025-59-7(Hazardous Substances Data)

Usage

Synthetic chemical compound

2,4-bis(2-chlorophenyl)-3-azabicyclo[3.3.1]nonan-9-one

Molecular structure

Bicyclic ketone

Functional groups

Two chlorophenyl groups

Applications

Organic synthesis, medicinal chemistry

Uses

Building block for other compounds, starting material for pharmaceutical development

Interest

Research and development in various scientific disciplines

Caution

Handling and use should consider safety and environmental impact.

Upstream product

• 108-94-1 cyclohexanone 
• 89-98-5 2-chloro-benzaldehyde 

Downstream Products

• 5706-78-5 2-chlorobenzaldehyde thiosemicarbazone 
• 1228657-83-7 C₂₁H₂₂Cl₂N₄S 
• 20158-14-9 2-chloro-benzaldehyde 4-phenyl-thiosemicarbazone 
• 1228657-90-6 C₂₁H₂₂Cl₂N₄O 
• 147225-36-3 2,4-bis(2-chlorophenyl)-3-azabicyclo[3.3.1]nonan-9-one oxime 
• 83651-06-3 (1S,2S,4R,5R,9R)-2,4-Bis-(2-chloro-phenyl)-3-aza-bicyclo[3.3.1]nonan-9-ol 

Relevant articles and documents

Synthesis, characterization and antitumor activities of some novel thiazinones and thiosemicarbazones derivatives

Two series of thiazinone and thiosemicarbazone derivatives (1-12) were synthesized using 2,4-diaryl-3-azabicyclo[3.3.1]nonan-9-ones (ABNs) and 3–alkyl–2,6–diarylpiperidin–4–ones as the starting materials. The structures of newly synthesized compounds were established on the basis of FT–IR, NMR spectroscopy and mass spectrometry. From the spectroscopic data, we identified that the cyclization reaction of thioamide with dialkyl acetylenedicarboxylate selectively gives six membered methyl 2-(2-(2,4-disubstituted-3-azabicyclo[3.3.1]nonan-9-ylidene)hydrazinyl)-4-oxo-4H-1,3-thiazine-6-carboxylates (1-6). In order to investigate the antitumor activities of the synthesized compounds, in?vitro cytotoxicity studies were carried out using human prostate cancer cell lines. Tested compounds showed good/moderate activities against cancer cell lines and further investigation carried out by live/dead assay.

Synthesis, stereochemistry and in vitro antimicrobial evaluation of novel 2-[(2,4-diaryl-3-azabicyclo[3.3.1]nonan-9-ylidene)hydrazono]-4-phenyl-2, 3-dihydrothiazoles

2-[(2,4-Diaryl-3-azabicyclo[3.3.1]nonan-9-ylidene)hydrazono]-4-phenyl-2, 3-dihydrothiazoles (3a-3k) have been synthesized by the cyclization of 2-[(2,4-diaryl-3-azabicyclo[3.3.1]nonan-9-one thiosemicarbazones with phenacyl bromide and characterized by ana

Synthesis, complete NMR spectral assignments, and antifungal screening of new 2,4-diaryl-3-azabicyclo[3.3.1]nonan-9-one oxime derivatives

A series of differently substituted 2,4-diaryl-3-azabicyclo[3.3.1]nonan-9- one oximes have been synthesized and their 1H and 13C NMR chemical shifts have been unambiguously assigned using H,H-COSY, NOESY, HSQC, and HMBC spectral data