341-23-1

Basic information

• Product Name: 4-FLUORO (1H)INDAZOLE
• Synonyms: 4-FLUORO (1H)INDAZOLE;4-Fuoro-1H-indazole;4-FLUOROINDAZOLE;1H-Indazole, 4-fluoro-
• CAS NO: 341-23-1
• Molecular Formula: C₇H₅FN₂
• Molecular Weight: 136.13
• Product Categories: Building Blocks;Indazole
• Mol File: 341-23-1.mol
• Article Data: 4

Chemical Properties

• Melting Point: 130.0 to 134.0 °C
• Boiling Point: 274.892 °C at 760 mmHg
• Flash Point: 120.051 °C
• Appearance: /
• Density: 1.371 g/cm³
• Vapor Pressure: 0.009mmHg at 25°C
• Refractive Index: 1.659
• Storage Temp.: Sealed in dry,Room Temperature
• Solubility: DMSO (Slightly), Methanol (Slightly)
• PKA: 13.21±0.40(Predicted)
• CAS DataBase Reference: 4-FLUORO (1H)INDAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-FLUORO (1H)INDAZOLE(341-23-1)
• EPA Substance Registry System: 4-FLUORO (1H)INDAZOLE(341-23-1)

Safety Data

• Hazard Codes: Xn
• Statements: 22
• Hazardous Substances Data: 341-23-1(Hazardous Substances Data)

Usage

Uses

4-Fluoro-1H-indazole

InChI:InChI=1/C7H5FN2/c8-6-2-1-3-7-5(6)4-9-10-7/h1-4H,(H,9,10)

Upstream product

• 443-86-7 3-fluoro-2-methylaniline 
• 13670-99-0 2,6-difluoroacetophenone 
• 437-81-0 2,6-difluorobenzaldehyde 
• 603-83-8 3-nitro-o-tolylamine 
• 769-10-8 1-fluoro-2-methyl-3-nitrobenzene 
• 388-22-7 benzoic acid-(3-fluoro-2-methyl-N-nitroso-anilide) 

Downstream Products

• 1178903-31-5 4-fluoro-1-(4-methoxybenzyl)-1H-indazole 
• 1178903-42-8 4-fluoro-2-(4-methoxybenzyl)-2H-indazole 
• 518990-32-4 4-fluoro-3-iodo-1H-indazole 
• 885521-60-8 3-bromo-4-fluoro-1H-indazole 
• 1561771-60-5 (3-bromo-4-fluoro-1H-indazol-1-yl)(2-chloro-6-(trifluoromethyl)phenyl)methanone 
• 1561949-67-4 ethyl 4-(1-{[2-chloro-6-(trifluoromethyl)phenyl]carbonyl}-4-fluoro-1H-indazol-3-yl)-1-methylcyclohex-3-ene-1-carboxylate 
• 1561949-41-4 4-(1-(2-chloro-6-(trifluoromethyl)benzoyl)-4-fluoro-1H-indazol-3-yl)-1-methylcyclohex-3-enecarboxylic acid 

Relevant articles and documents

Fluorinated analogues of marsanidine, a highly α2-AR/imidazoline I1 binding site-selective hypotensive agent. Synthesis and biological activities

The aim of these studies was to establish the influence of fluorination of the indazole ring on the pharmacological properties of two selective α2-adrenoceptor (α2-AR) agonists: 1-[(imidazolidin-2-yl)imino]-1H-indazole (marsanidine,

4-Substituted indazoles as new inhibitors of neuronal nitric oxide synthase

A series of halo-1-H-indazoles has been synthesized and evaluated for its inhibitory activity on neuronal nitric oxide synthase. Introduction of bromine at the C4 position of the indazole ring system provided a compound almost as potent as the reference compound, that is, 7-nitroindazole (7-NI). The importance of position 4 is further demonstrated by the synthesis and pharmacological evaluation of the 4-nitroindazole which was also a potent inhibitor of NOS activity. These compounds also exhibited in vivo NOS inhibitory activity, as attested by potent antinociceptive effects following systemic administration.