34154-81-9

Basic information

• Product Name: Benzenemethanol, a-[1-(diethylamino)ethyl]-,(R*,R*)- (9CI)
• Synonyms: Benzylalcohol, a-[1-(diethylamino)ethyl]-, threo-(8CI); threo-1-Phenyl-2-diethylamino-1-propanol
• CAS NO: 34154-81-9
• Molecular Formula: C₁₃H₂₁NO
• Molecular Weight: 207.3119
• Product Categories: Aliphatics;Amines;Metabolites & Impurities
• Mol File: 34154-81-9.mol
• Article Data: 1

Chemical Properties

• Melting Point: 229-232 °C(Solv: ethanol (64-17-5))
• Boiling Point: 311.36°C at 760 mmHg
• Flash Point: 111.939°C
• Appearance: /
• Density: 0.984g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.521
• Storage Temp.: Refrigerator
• Solubility: Chloroform (Slightly), Ethanol (Slightly), Ethyl Acetate (Slightly)
• PKA: 13.89±0.20(Predicted)
• CAS DataBase Reference: Benzenemethanol, a-[1-(diethylamino)ethyl]-,(R*,R*)- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenemethanol, a-[1-(diethylamino)ethyl]-,(R*,R*)- (9CI)(34154-81-9)
• EPA Substance Registry System: Benzenemethanol, a-[1-(diethylamino)ethyl]-,(R*,R*)- (9CI)(34154-81-9)

Safety Data

• Hazardous Substances Data: 34154-81-9(Hazardous Substances Data)

Usage

Description

Benzenemethanol, a-[1-(diethylamino)ethyl]-,(R,R)(9CI) is an organic compound with a complex structure, featuring a benzene ring, a methanol group, and a diethylaminoethyl group. It is characterized by its chiral centers (R,R), which give it unique stereochemical properties. Benzenemethanol, a-[1-(diethylamino)ethyl]-,(R,R)(9CI) is primarily known as a metabolite of Diethylpropione, a substance with various applications in different industries.

Uses

Used in Pharmaceutical Industry:
Benzenemethanol, a-[1-(diethylamino)ethyl]-,(R,R)(9CI) is used as an intermediate in the synthesis of various pharmaceutical compounds. Its unique structure and chiral properties make it a valuable building block for the development of new drugs with potential therapeutic applications.
Used in Chemical Research:
In the field of chemical research, Benzenemethanol, a-[1-(diethylamino)ethyl]-,(R,R)(9CI) serves as a key compound for studying the properties and reactivity of chiral molecules. Its synthesis and manipulation can provide insights into the development of novel synthetic methods and the understanding of stereoselective reactions.
Used in Analytical Chemistry:
As a chiral compound, Benzenemethanol, a-[1-(diethylamino)ethyl]-,(R,R)(9CI) can be employed as a reference material in analytical chemistry. It can be used to calibrate and validate chromatographic and spectroscopic methods, ensuring the accurate determination of enantiomeric purity and the study of stereoselective processes.

InChI:InChI=1/C13H21NO/c1-4-14(5-2)11(3)13(15)12-9-7-6-8-10-12/h6-11,13,15H,4-5H2,1-3H3/t11-,13+/m0/s1

Upstream product

• 90-84-6 amfepramone 

Relevant articles and documents

THE STEREOSELECTIVE REDUCTION OF α-AMINOPROPIOPHENONE DERIVATIVES WITH SODIUM BOROHYDRIDE

The ratio of erythro and threo products from the sodium borohydride reduction of the hydrochlorides, and other acid salts, of α-aminopropiophenone derivatives was determined.It was found that this procedure resulted in stereoselective formation of erythro-2-amino-1-phenylpropanols in contrast to sodium borohydride reduction of the corresponding free bases.The method was successfully applied to the synthesis of dl-erythro-2-(4-benzylpiperidino)-1-(4-hydroxyphenyl)propanol which has been used as a vasodilator.