3416-22-6

Basic information

• Product Name: CALCIUM FUMARATE
• Synonyms: CALCIUM FUMARATE;FUMARIC ACID CALCIUM SALT;calcium fumarate (1:2)
• CAS NO: 3416-22-6
• Molecular Formula: C₄H₂O₄*Ca
• Molecular Weight: 154.13
• EINECS: 222-310-7
• Mol File: 3416-22-6.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 355.5°Cat760mmHg
• Flash Point: 183°C
• Appearance: /
• Density: g/cm³
• Vapor Pressure: 5.19E-06mmHg at 25°C
• CAS DataBase Reference: CALCIUM FUMARATE(CAS DataBase Reference)
• NIST Chemistry Reference: CALCIUM FUMARATE(3416-22-6)
• EPA Substance Registry System: CALCIUM FUMARATE(3416-22-6)

Safety Data

• Hazardous Substances Data: 3416-22-6(Hazardous Substances Data)

Usage

General Description

Calcium fumarate is a chemical compound that consists of calcium and fumaric acid. It is commonly used as a calcium supplement in food and pharmaceutical products. Calcium is an essential mineral that is important for maintaining strong bones and teeth, as well as for nerve and muscle function. Fumaric acid, on the other hand, is a naturally occurring organic acid that is found in various fruits and vegetables. When combined, calcium fumarate serves as a readily absorbable form of calcium that can be easily utilized by the body. It is widely utilized in the food industry as a food additive to fortify products with calcium, particularly in dairy and baked goods, as well as in the pharmaceutical industry as a dietary supplement.

InChI:InChI=1/2C4H4O4.Ca/c2*5-3(6)1-2-4(7)8;/h2*1-2H,(H,5,6)(H,7,8);/q;;+2/p-2/b2*2-1+;

Upstream product

• 110-17-8 (2E)-but-2-enedioic acid 
• 87-69-4 tartaric acid 
• 108-31-6 maleic anhydride 
• 110-16-7 maleic acid 
• 115609-54-6 C₈H₆O₅^(2-)*Ca⁽²⁺⁾ 

Downstream Products

• 110-17-8 (2E)-but-2-enedioic acid 

Relevant articles and documents

Application of calcium carbonate nanoparticles and microwave irradiation in submerged fermentation production and recovery of fumaric acid: A novel approach

The aim of the present study was to explore the possible application of calcium carbonate nanoparticles (CCNPs) and microwave irradiation (MWI) in fumaric acid (FA) production and recovery, respectively. The fungal strain Rhizopus oryzae 1526 was employed as the biocatalyst for FA production. A glucose-basic salt medium was used as the fermentation medium. Scanning electron microscopy (SEM) analysis of CCNPs displayed the spherical shapes, while zetasizer measurements showed the CCNPs to be around 190 ± 20 nm in size. FTIR analysis of CCNPs confirmed the chemical composition. BET analysis confirmed higher specific surface areas of CCNPs (11.95 ± 0.03 m2 g-1) compared to calcium carbonate microparticles (CCMPs) (3.51 ± 0.02 m2 g-1). FA neutralization timing for CCNPs was much lower than CCMPs (190 and 350 seconds, respectively). CCNPs enhanced the volumetric productivity of FA from 0.47 g L-1 h-1 to 0.74 g L-1 h-1. At 20, 40 and 60 g L-1 concentrations and at 25 °C, viscosities of the CCNPs were found to be lower than respective CCMPs. Moreover, the CCNPs did not exhibit any toxicity towards the fungus. FA production obtained with CC micro and CCNPs were 67.34 ± 2 g L-1 and 66.92 ± 2.7 g L-1, respectively. Under MWI heating, 10 ± 1 min was found to be sufficient for recovery of FA and this was much lower than conventional heating timing of 28 ± 1 min.

Chemical process

There is disclosed herein improved processes for the preparation of ether carboxylates by reacting in an alkaline reaction medium the salts of maleic acid and a carboxylic or polycarboxylic acid having a reactive hydroxyl group on a non-carbonyl carbon atom in the presence of a calcium ion catalyst wherein unreacted acid salts are recovered from the reaction medium by lowering the pH of the reaction medium to a range of from about 4 to about 6. The precipitated salts are recycled to the synthesis reaction to prepare additional amounts of product.