34232-27-4 Usage
Description
5,8-Dihydroxy-2-[(S)-1-acetoxy-4-methyl-3-pentenyl]-1,4-naphthalenedione, also known as asperbenzaldehyde A, is a complex chemical compound derived from the marine-derived fungus Aspergillus. It features a naphthalene backbone with two hydroxyl groups and a unique pentenyl side chain with an acetoxy group. This natural product has garnered attention for its potential biological activity, particularly in the areas of antitumor and antifungal properties, making it a promising candidate for medicinal chemistry research and drug development.
Uses
Used in Pharmaceutical Industry:
5,8-Dihydroxy-2-[(S)-1-acetoxy-4-methyl-3-pentenyl]-1,4-naphthalenedione is used as a lead compound for antitumor drug development due to its demonstrated biological activity against cancer cells. Its unique structure allows for further exploration and modification to enhance its therapeutic potential and target specific types of cancer.
Used in Antifungal Applications:
In the field of antifungal research, 5,8-Dihydroxy-2-[(S)-1-acetoxy-4-methyl-3-pentenyl]-1,4-naphthalenedione is utilized as a natural product with potential antifungal properties. Its ability to combat fungal infections makes it a valuable resource for developing new antifungal agents to address the growing issue of drug-resistant fungi.
Used in Medicinal Chemistry Research:
5,8-Dihydroxy-2-[(S)-1-acetoxy-4-methyl-3-pentenyl]-1,4-naphthalenedione serves as an interesting target for medicinal chemistry research. Its complex structure and potential biological activity provide a foundation for scientists to study its mechanisms of action and optimize its properties for various therapeutic applications.
Overall, the compound's unique features and potential applications across different fields highlight its significance in the ongoing pursuit of novel therapeutic agents and drug development strategies.
Check Digit Verification of cas no
The CAS Registry Mumber 34232-27-4 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,4,2,3 and 2 respectively; the second part has 2 digits, 2 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 34232-27:
(7*3)+(6*4)+(5*2)+(4*3)+(3*2)+(2*2)+(1*7)=84
84 % 10 = 4
So 34232-27-4 is a valid CAS Registry Number.
34232-27-4Relevant articles and documents
Design and synthesis of fluoroacylshikonin as an anticancer agent
Kong, Wen-Yao,Chen, Xiao-Feng,Shi, Jing,Baloch, Shahla Karim,Qi, Jin-Liang,Zhu, Hai-Liang,Wang, Xiao-Ming,Yang, Yong-Hua
, p. 757 - 762 (2013/11/06)
A series of shikonin derivatives, selectively acylated by various fluorinated carboxylic acids at the side chain of shikonin, were synthesized and their anticancer activity evaluated, in which eight compounds are reported for the first time. Among all the compounds tested, compound S7 showed the most potent anticancer activity against B16-F10 (malignant melanoma cells), MG63 (human osteosarcoma cells), and A549 (lung cancer cells) with IC50 0.39 ± 0.01, 0.72 ± 0.04 and 0.58 ± 0.02 μmol/L. Docking simulation of compound S7 was carried out to position S7 into a tubulin active site to determine the probable binding conformation. All the results suggested that compound S7 may be a potential anticancer agent. Chirality 25:757-762, 2013. 2013 Wiley Periodicals, Inc. Copyright
Acylshikonin analogues: Synthesis and inhibition of DNA topoisomerase-I
Ahn,Baik,Kweon,Lim,Hwang
, p. 1044 - 1047 (2007/10/02)
Compounds bearing an acyl group of a various size at 1'-OH of shikonin were synthesized as acyl analogues of shikonin, which was isolated from the root of Lithospermum erythrorhizon, and evaluated for inhibitory effect on topoisomerase-I activity. A selec
