34256-00-3Relevant articles and documents
Guaiacol intermediate and preparation method thereof
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Paragraph 0031; 0032; 0033, (2016/10/10)
The invention provides a guaiacol intermediate. A structure formula of the guaiacol intermediate is as shown in the description. The invention also provides a preparation method of the guaiacol intermediate. The preparation method comprises the following
Acid-catalyzed transfer sulfonation of anisole using overcrowded polymethylbenzenesulfonic acids
Koeberg-Telder, Ankie,Cerfontain, Hans
, p. 41 - 45 (2007/10/02)
Transfer sulfonations of anisole using various polymethylbenzenesulfonic acids (PoMBR's) catalyzed by trifluoromethanesulfonic acid at 25 deg C are described.The observed reactivity order for transfer sulfonation increases in the order 2,4-DiMBS, 2,6-DiMB
Aromatic Sulphonation. Part 91. The Sulphonation of Anisole, Phenol, Phenyl Methanesulphonate, Potassium Phenyl Sulphate, and a Series of Methyl-, Bromo-, and Chloro-substituted Anisoles and Phenols in Concentrated Aqueous Sulphuric Acid
Cerfontain, Hans,Lambrechts, Hans J. A.,Schaasberg-Nienhuis, Zwaan R. H.,Coombes, Robert G.,Hadjigeorgiou, Panicos,Tucker, Geoffrey
, p. 659 - 668 (2007/10/02)
The (homogeneous) sulphonation of a number of aromatic ethers and alcohols, viz. anisole (1), 3-methyl- (2), 4-methyl- (3), 2-bromo- (4), 4-bromo- (5), 2-chloro- (6), and 4-chloro-anisole (7), phenol (8), 2-methyl- (9), 3-methyl- (10), 4-methyl- (11), 4-bromo- (12), 2-chloro- (13), and 4-chloro-phenol (14), phenyl methanesulphonate (15), and potassium phenyl sulphate (16) in concentrated aqueous sulphuric acid at 25.0 deg C has been studied, and rates and isomer distributions have been determined.The sulphonation is first-order in the aromatic substrate, and from the rate measurements it is concluded that the species undergoing sulphonation in the phenyl ring is an unprotonated substrate species.In the lower acid concentrations the sulphonating entity is H3SO4(1+).With increasing sulphuric acid concentration there is a gradual change-over in the sulphonating entity from H3SO4(1+) to H2S2O7.The acid concentrations of equal rate contribution by the two entities for anisole and phenol are 87 and 90 +/- 1percent, respectively.Sulphonation on the oxygen atom (i.e., sulphation) does not occur.The o/p-ratios for (1) and (8) do not vary over the studied sulphuric acid range of 75-90percent H2SO4.Partial rate factors for the 2- and 4-position of (1) and (8) are reported.The very low partial rate factors for the 4-substitution of (1) and (8) and the observed extreme suppression and compression of the reactivities of the substrates (1)-(14) are ascribed to hydrogen bonding of the substrates with the acidic solvent species present.It is tentatively suggested that the relatively high contents of sulphonation ortho to -OR with anisole (36percent) and phenol (48percent) are due to specific complexation of the substrates with the sulphonating electrophile.
