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34259-91-1

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34259-91-1 Usage

Check Digit Verification of cas no

The CAS Registry Mumber 34259-91-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,4,2,5 and 9 respectively; the second part has 2 digits, 9 and 1 respectively.
Calculate Digit Verification of CAS Registry Number 34259-91:
(7*3)+(6*4)+(5*2)+(4*5)+(3*9)+(2*9)+(1*1)=121
121 % 10 = 1
So 34259-91-1 is a valid CAS Registry Number.

34259-91-1Relevant articles and documents

Novel pyridylmethylamines as highly selective 5-HT1A superagonists

Bollinger, Stefan,Hübner, Harald,Heinemann, Frank W.,Meyer, Karsten,Gmeiner, Peter

scheme or table, p. 7167 - 7179 (2010/12/19)

To further improve the maximal serotonergic efficacy and better understand the configurational requirements for 5-HT1A binding and activation, we generated and biologically investigated structural variants of the lead structure befiradol. For a bioisosteric replacement of the 3-chloro-4-fluoro moiety, a focused library of 63 compounds by solution phase parallel synthesis was developed. Target binding of our compound collection was investigated, and their affinities for 5-HT2, α1, and α2-adrenergic as well as D1-D4 dopamine receptors were compared. For particularly interesting test compounds, intrinsic activities at 5-HT1A were examined in vitro employing a GTPγS assay. The investigation guided us to highly selective 5HT1A superagonists. The benzothiophene-3-carboxamide 8bt revealed almost exclusive 5HT1A recognition with a Ki value of 2.7 nM and a maximal efficacy of 124%. To get insights into the bioactive conformation of our compound collection, we synthesized conformationally constrained bicyclic scaffolds when SAR data indicated a chair-type geometry and an equatorially dispositioned aminomethyl substituent for the 4,4-disubstituted piperidine moiety.

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