34272-64-5

Basic information

• Product Name: 2-Mercapto-4-methyl-5-thiazoleacetic acid
• Synonyms: 2-mercapto-4-methyl-5-thiazoleaceticaci;2-MERCAPTO-4-METHYL-5-THIAZOLEACETIC ACID;2-MERCAPTO-4-METHYLTHIAZOLE-5-ACETIC ACID;MMTA;2,3-dihydro-4-methyl-2-thioxothiazol-5-acetic acid;2-MERCAPTO-4-METHYL-5-THIAZOLE ACETIC ACID(MMTA);2-mercapto-4-methylthiazole-5-yl acetic acid;2-Mercapto-4-Methyl-5-Thiazole
• CAS NO: 34272-64-5
• Molecular Formula: C₆H₇NO₂S₂
• Molecular Weight: 189.26
• EINECS: 251-905-4
• Product Categories: Organic acids;Heterocyclic Compounds;Building Blocks;Heterocyclic Building Blocks;Thiazoles
• Mol File: 34272-64-5.mol
• Article Data: 4

Chemical Properties

• Melting Point: 207 °C (dec.)(lit.)
• Boiling Point: 363.4 °C at 760 mmHg
• Flash Point: 173.6 °C
• Appearance: white to light yellow crystal powder
• Density: 1.52 g/cm³
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 4.09±0.10(Predicted)
• CAS DataBase Reference: 2-Mercapto-4-methyl-5-thiazoleacetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 2-Mercapto-4-methyl-5-thiazoleacetic acid(34272-64-5)
• EPA Substance Registry System: 2-Mercapto-4-methyl-5-thiazoleacetic acid(34272-64-5)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26-36
• RIDADR: UN 3335
• WGK Germany: 3
• RTECS: XJ1921000
• Hazardous Substances Data: 34272-64-5(Hazardous Substances Data)

Usage

Chemical Properties

white to light yellow crystal powde

Uses

2-Mercapto-4-methyl-5-thiazoleacetic acid may be used as a capping agent in the preparation of fused spherical gold nanoparticles. It may also be used in the synthesis of eight-tin macrocyclic complex (a 40-membered macrocycle containing two distannoxane ladders).

General Description

2-Mercapto-4-methyl-5-thiazoleacetic acid is a thiazole derivative. It participates in the preparation of dinuclear [Au-(O4NCS2)]2 and tetranuclear [Au(SSCOOH)]4 complexes.

Upstream product

• 111874-19-2 (4-methyl-2-thioxo-2,3-dihydro-thiazol-5-yl)-acetic acid ethyl ester 
• 54260-84-3 ethyl 3-bromo-4-oxopentanoate 
• 86329-79-5 Kenicef 
• 513-74-6 ammonium dithiocarbamate 
• 123-76-2 levulinic acid 
• 99968-96-4 methyl 3-chlorolevulinate 

Relevant articles and documents

Synthesis method of 2-sulfydryl-4-methyl-5-thiazole acetic acid

The invention relates to a synthesis method of a 2-sulfydryl-4-methyl-5-thiazole acetic acid. The synthesis method comprises the following steps: adding a levulinic acid and an organic solvent into areaction kettle, adding a compound A, slowly adding a catalyst, stirring, raising the temperature to 40-60 DEG C, preserving the heat for 2-2.5 hours, adding water for washing, layering to obtain an organic phase, directly adding ammonium dithiocarbamate, water and a compound B into the organic phase to perform a ring-closure reaction, layering after finishing the reaction to obtain an aqueous phase, and regulating the pH of the aqueous phase to obtain the 2-sulfydryl-4-methyl-5-thiazole acetic acid. The synthesis method is simple in operation, high in yield, low in cost and short in operationcycle, and is easy to control. The heterogeneous reaction is realized, the procedure of distilling the organic solvent is reduced, the reaction procedure is reduced, and the production time is shortened. The power consumption is reduced. The loss of the organic solvent in the distilling process is reduced, and the environment pollution caused by the organic solvent is further reduced.

Alkaline and neutral degradation of cefodizime (THR-221) and structural elucidation of the products. II

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