34276-53-4

Basic information

• Product Name: ETHYL 4-NITRO-L-PHENYLALANINE
• Synonyms: ETHYL 4-NITRO-L-PHENYLALANINE;L-Phenylalanine, 4-nitro-, ethyl ester;p-Nitro-L-phenylalanine ethyl ester;(S)-Ethyl 2-amino-3-(4-nitrophenyl)propanoate;4-NO2-Phe-Oet
• CAS NO: 34276-53-4
• Molecular Formula: C₁₁H₁₄N₂O₄
• Molecular Weight: 238.25
• Mol File: 34276-53-4.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 372.1 °C at 760 mmHg
• Flash Point: 178.9 °C
• Appearance: /
• Density: 1.246 g/cm³
• Storage Temp.: Keep in dark place,Sealed in dry,Store in freezer, under -20°C
• PKA: 6.62±0.33(Predicted)
• CAS DataBase Reference: ETHYL 4-NITRO-L-PHENYLALANINE(CAS DataBase Reference)
• NIST Chemistry Reference: ETHYL 4-NITRO-L-PHENYLALANINE(34276-53-4)
• EPA Substance Registry System: ETHYL 4-NITRO-L-PHENYLALANINE(34276-53-4)

Safety Data

• Hazardous Substances Data: 34276-53-4(Hazardous Substances Data)

Usage

General Description

ETHYL 4-NITRO-L-PHENYLALANINE is a chemical compound that is classified as an amino acid derivative, more specifically an L-phenylalanine derivative. It contains an ethyl ester group and a nitro group, which gives it its special properties. It's used mainly for scientific and biochemical research purposes. As with any chemical substance, handling should be with caution because its health effects have not been thoroughly studied yet. Its molecular formula is C11H14N2O4. ETHYL 4-NITRO-L-PHENYLALANINE is a stereoisomer, meaning it has a similar molecular formula to other compounds but a different structural geometry. It, like other chemicals, is identified by a unique CAS Registry Number used globally to provide consistent and reliable identification.

Upstream product

• 63-91-2 L-phenylalanine 
• 86937-80-6 2-tert-butoxycarbonylamino-3-(4-nitro-phenyl)-propionic acid 
• 36097-39-9 (S)-methyl 2-acetamido-3-(4-nitrophenyl)propanoate 
• 64-17-5 ethanol 
• 147065-06-3 L-nitrophenylalanine hydrochloride 
• 555-16-8 4-nitrobenzaldehdye 
• 58816-66-3 (S)-2-amino-3-(4-nitrophenyl)propionic acid ethyl ester hydrochloride 
• 949-99-5 4-nitro-3-phenyl-L-alanine 

Downstream Products

• 644995-08-4 3-(4-nitrophenyl)-2(S)-(3-oxospiro[3.5]non-1-en-1-ylamino)propionic acid ethyl ester 
• 1082075-20-4 (2S)-3-[2-(2,6-dichlorophenyl)quinolin-6-yl]-2-{[methyl(phenyl)carbamoyl]amino}propanoic acid 
• 792864-20-1 N-phthalimido-4-(bis-2-chloroethyl)amino-L-phenylalanine ethyl ester 
• 97338-02-8 N-phthalimido-4-(bis-2-hydroxyethyl)amino-L-phenylalanine ethyl ester 
• 74743-23-0 N-phthalimido-4-amino-L-phenylalanine ethyl ester 
• 17451-67-1 N-phthalimido-4-nitro-L-phenylalanine ethyl ester 
• 1070730-55-0 ethyl (2S)-2-[(tert-butoxycarbonyl)amino]-3-[2-(2,6-dichlorophenyl)-6-quinolinyl]-propanoate 
• 1031337-85-5 ethyl N-(4,4-dimethyl-3-oxocyclobut-1-en-1-yl)-4-nitro-L-phenylalaninate 
• 1031822-14-6 ethyl N-[(4R,7S)-7-(benzyloxy)-3-oxospiro[3.5]non-1-en-1-yl]-4-nitro-L-phenylalaninate 
• 174775-10-1 ethyl (S)-3-(4-aminophenyl)-2-(benzyloxycarbonylamino)propionate 
• 121612-81-5 5-[(S)-1-Hydroxymethyl-2-(4-nitro-phenyl)-ethylcarbamoyl]-7-methyl-thieno[2,3-b]pyridin-7-ium; iodide 
• 121635-42-5 (S)-2-(N-methyl-4,7-dihydrothieno<2,3-b>pyridine-5-carbonylamino)-3-(4-nitrophenyl)propan-1-ol 
• 121612-75-7 (S)-3-(4-nitrophenyl)-2-(thieno<2,3-b>pyridine-5-carbonylamino)propan-1-ol 
• 89288-22-2 (S)-(-)-2-amino-3-(4-nitrophenyl)propan-1-ol 

Relevant articles and documents

Melphalan intermediate and preparation method thereof

The invention discloses a Melphalan intermediate and a preparation method thereof. The Melphalan intermediate is prepared by acidifying a compound p-nitrobenzaldehyde under the action of methanol, a hydrochloric acid solvent, etc. The preparation method has a route with mild reaction conditions, is higher than an existing preparation method in yield, is economical and effective, and is suitable for large-scale industrial production. The synthesis route is as shown in the description.

PROCESS FOR THE PREPARATION OF PHENYLALANINE ENAMIDE DERIVATIVES

A process for the preparation of a class of phenylalanine enamide derivatives is described formula (1) wherein: Ar1 is an optionally substituted aromatic or heteroaromatic group; L2 is a linker group selected from -N(R4)- [where R4 is a hydrogen atom or an optionally substituted straight or branched C1-6alkyl group], -CON(R4)-, or -S(O)2N(R4)-; R1 is a carboxylic acid (-CO2H) or a derivative or biostere thereof; R2 is a hydrogen atom or a C1-6alkyl group; Rx, Ry and Rz which may be the same or different is each an atom or group -L1(Alk1)n(R3)v; and the salts, solvates, hydrates and N-oxides thereof; which comprises reacting a compound of formula (2): wherein: Qa is a group -N(R4)H; and the salts, solvates, hydrates and N-oxides thereof; with a compound Ar1W wherein W is a group selected from X1 (wherein X1 is a leaving atom or group), -COX2 (wherein X2 is a halogen atom or a -OH group) or -SO2 X3 (in which X3 is a halogen atom).