343-90-8

Basic information

• Product Name: 5-FLUOROGRAMINE
• Synonyms: 3-((dimethylamino)methyl)-5-fluoroindole;3-(dimethylamino)methyl-5-fluoro-indol;5-fluoro-n,n-dimethyl-1h-indole-3-methanamin;(5-FLUORO-1H-INDOL-3-YLMETHYL)-DIMETHYL-AMINE;5-FLUORO-3-DIMETHYLAMINOMETHYL-1H-INDOLE;5-FLUORO-3-(DIMETHYLAMINOMETHYL)INDOLE;5-FLUOROGRAMINE;3-(Dimethylaminomethyl)-5-fluoro-1H-indole
• CAS NO: 343-90-8
• Molecular Formula: C₁₁H₁₃FN₂
• Molecular Weight: 192.23
• Product Categories: Indoles and derivatives
• Mol File: 343-90-8.mol
• Article Data: 9

Chemical Properties

• Melting Point: 145-149°C
• Boiling Point: 297.68 °C at 760 mmHg
• Flash Point: 133.832 °C
• Appearance: /
• Density: 1.182 g/cm³
• Vapor Pressure: 0.00133mmHg at 25°C
• Refractive Index: 1.61
• Storage Temp.: 2-8°C(protect from light)
• CAS DataBase Reference: 5-FLUOROGRAMINE(CAS DataBase Reference)
• NIST Chemistry Reference: 5-FLUOROGRAMINE(343-90-8)
• EPA Substance Registry System: 5-FLUOROGRAMINE(343-90-8)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 343-90-8(Hazardous Substances Data)

Usage

General Description

5-Fluorogramine is a chemical compound that belongs to the class of fluorinated alkaloids and contains a fluorine atom. It is a synthetic derivative of the natural alkaloid gramine and has shown potential in pharmaceutical research and drug development. 5-Fluorogramine has been studied for its potential antitumor and anticancer properties, as well as for its ability to modulate neurotransmitter receptors in the central nervous system. It has also been investigated for its potential as a tool molecule for studying the structure and function of certain receptors and ion channels in the brain. Overall, 5-Fluorogramine is a versatile and promising chemical compound with various potential applications in the fields of medicine, pharmacology, and neuroscience.

InChI:InChI=1/C11H13FN2/c1-14(2)7-8-6-13-11-4-3-9(12)5-10(8)11/h3-6,13H,7H2,1-2H3

Upstream product

• 399-52-0 5-fluoro-1H-indole 
• 33797-51-2 eschenmoser's salt 
• 50-00-0 formaldehyd 
• 506-59-2 N,N-dimethylammonium chloride 
• 782-10-5 (5-fluoro-2-nitro-phenyl)-pyruvic acid 
• 351-64-4 ethyl 2-[2-(4-fluorophenyl)hydrazinylidene]propanoate 
• 124-40-3 dimethyl amine 
• 399-76-8 5-fluoroindole-2-carboxylic acid 
• 348-36-7 ethyl 5-fluoro-1H-indole-2-carboxylate 

Downstream Products

• 443-73-2 (5-fluoroindol-3-yl)acetic acid 
• 73139-85-2 2-(5-fluoro-1H-indol-3-yl)acetonitrile 
• 154170-01-1 ethyl 2-amino-3-(5-fluoro-1H-indol-3-yl)propanoate 
• 154-08-5 DL-5-fluorotryptophan 
• 215997-93-6 di(5-fluoro-1H-indole-3-yl)methane 
• 16626-02-1 5-fluoro-L-tryptophan 
• 114926-41-9 (S)-2-((tert-butoxycarbonyl)amino)-3-(5-fluoro-1H-indol-3-yl)propanoic acid 

Relevant articles and documents

SMALL MOLECULES THAT TARGET THE RNA THAT CAUSES ALS

Disclosed herein are compounds that selectively bind an expanded transcribed repeat r(G4C2)exp, prevent sequestration of RNA-binding proteins, and inhibit translation of repeat associated non-ATG (RAN) translation responsible for generation of toxic dipeptide repeats underlying diseases such as amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD). The compounds and their pharmaceutical compositions are useful in treating a disease or condition characterized by an expanded G4C2 repeat RNA (r(G4C2)exp), such as ALS and FTD.

NOVEL DUAL MODE OF ACTION SOLUBLE GUANYLATE CYCLASE ACTIVATORS AND PHOSPHODIESTERASE INHIBITORS AND USES THEREOF

The present invention relates to compounds of formula (I), or pharmaceutically acceptable salt, solvate or hydrate thereof, wherein said compound of formula (I) comprises at least one covalently bound -ONO2 or -ONO moiety and at most four covalently bound -ONO2 or -ONO moieties, and wherein AR, R1, X, R3 and R4 are as defined in claim 1; and pharmaceutical compositions thereof, and their use in methods of treating or preventing a disease alleviated by inhibition of PDE5 in a human or in a non-human mammal.

Rhodium-Catalyzed Diastereo- And Enantioselective Tandem Spirocyclization/Reduction of 3-Allenylindoles: Access to Functionalized Vinylic Spiroindolines

A highly selective rhodium-catalyzed tandem spirocyclization/reduction of 3-allenylindoles is reported. By employing a Hantzsch ester as reductant, vinylic spiroindolines are obtained in excellent yields as well as diastereo- and enantioselectivity. In addition, the reaction's synthetic utility is highlighted by broad functional group compatibility and exemplified by a gram scale reaction with subsequent assorted transformations.