34310-29-7

Basic information

• Product Name: N-MethyltrifluoroMethanesulfonaMide
• Synonyms: N-MethyltrifluoroMethanesulfonaMide;Methanesulfonamide, 1,1,1-trifluoro-N-methyl-;N-MethyltrifluoroMethanesulfoMide
• CAS NO: 34310-29-7
• Molecular Formula: C₂H₄F₃NO₂S
• Molecular Weight: 163.1188696
• Mol File: 34310-29-7.mol
• Article Data: 8

Chemical Properties

• Boiling Point: 80℃ (10 Torr)
• Flash Point: 26.1±30.1 °C
• Appearance: /
• Density: 1.5±0.1 g/cm³
• PKA: 7.56±0.40(Predicted)
• CAS DataBase Reference: N-MethyltrifluoroMethanesulfonaMide(CAS DataBase Reference)
• NIST Chemistry Reference: N-MethyltrifluoroMethanesulfonaMide(34310-29-7)
• EPA Substance Registry System: N-MethyltrifluoroMethanesulfonaMide(34310-29-7)

Safety Data

• Hazardous Substances Data: 34310-29-7(Hazardous Substances Data)

Usage

General Description

N-Methyltrifluoromethanesulfonamide is a chemical compound with the molecular formula C2H3F3NO2S. It is a colorless liquid that is widely used as a strong and non-nucleophilic base in a variety of chemical reactions. It is also used as a reagent in organic synthesis, particularly in the fluorination of organic compounds. N-Methyltrifluoromethanesulfonamide is known for its ability to act as a source of trifluoromethyl cation, making it a valuable tool in the development of pharmaceuticals and agrochemicals. It is also used in the manufacturing of various specialty chemicals and materials. Due to its strong basic and nucleophilic properties, it is important to handle and use N-Methyltrifluoromethanesulfonamide with caution and in accordance with proper safety protocols.

Upstream product

• 421-83-0 trifluoromethane sulfonyl chloride 
• 593-51-1 methylamine hydrochloride 
• 358-23-6 trifluoromethylsulfonic anhydride 
• 335-05-7 Trifluoromethanesulfonyl fluoride 
• 74-89-5 methylamine 

Downstream Products

• 130061-49-3 Benzoic acid 3-(methyl-trifluoromethanesulfonyl-amino)-butyl ester 
• 129990-96-1 (R)-(-)-3-<(N-methyl-N-trifluoromethanesulfonyl)amino>-1-butanol benzoate 
• 129991-11-3 (S)-(+)-3-<(N-methyl-N-trifluoromethanesulfonyl)amino>-1-butanol benzoate 
• 51029-13-1 N-benzyl-N-methyl triflamide 

Relevant articles and documents

Intermolecular Radical C(sp3)?H Amination under Iodine Catalysis

The direct amination of aliphatic C?H bonds has remained one of the most tantalizing transformations in organic chemistry. Herein, we report on a unique catalyst system, which enables the elusive intermolecular C(sp3)?H amination. This practical synthetic strategy provides access to aminated building blocks and fosters innovative multiple C?H amination within a new approach to aminated heterocycles. The synthetic utility is demonstrated by the synthesis of four relevant pharmaceuticals.

Photoredox-Catalyzed Site-Selective α-C(sp3)?H Alkylation of Primary Amine Derivatives

The synthetic utility of tertiary amines to oxidatively generate α-amino radicals is well established, however, primary amines remain challenging because of competitive side reactions. This report describes the site-selective α-functionalization of primary amine derivatives through the generation of α-amino radical intermediates. Employing visible-light photoredox catalysis, primary sulfonamides are coupled with electron-deficient alkenes to efficiently and mildly construct C?C bonds. Interestingly, a divergence between intermolecular hydrogen-atom transfer (HAT) catalysis and intramolecular [1,5] HAT was observed through precise manipulation of the protecting group. This dichotomy was leveraged to achieve excellent α/δ site-selectivity.

N-sulfonylaminocarbonyl containing compounds

Compounds having two reactive functional groups are described that can be used to provide a connector group between a substrate and an amine-containing material. The first reactive functional group can be used to provide attachment to a surface of a subst