34329-73-2 Usage
Description
Methyl 3-bromo-2-oxobutanoate, also known as 3-bromo-2-oxobutanoic acid methyl ester, is a chemical compound that serves as a phosphoenolpyruvate (PEP) analog. It is characterized by its molecular structure, which closely resembles that of PEP, allowing it to be used in various biochemical and pharmaceutical applications.
Uses
Used in Research and Development:
Methyl 3-bromo-2-oxobutanoate is used as a research tool for studying pyruvate kinase, an enzyme that plays a crucial role in cellular metabolism. By acting as a PEP analog, it helps researchers understand the enzyme's function, mechanism, and potential as a therapeutic target for various diseases.
Used in Pharmaceutical Industry:
In the pharmaceutical industry, Methyl 3-bromo-2-oxobutanoate is utilized as a starting material or intermediate in the synthesis of various drugs and drug candidates. Its structural similarity to PEP makes it a valuable compound for designing and developing novel therapeutic agents that target pyruvate kinase or related metabolic pathways.
Used in Biochemical Analysis:
Methyl 3-bromo-2-oxobutanoate is also employed in biochemical analysis as a reagent to investigate the activity and specificity of pyruvate kinase and other enzymes involved in metabolic processes. This helps researchers gain insights into the regulation of these enzymes and their role in cellular metabolism.
Check Digit Verification of cas no
The CAS Registry Mumber 34329-73-2 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,4,3,2 and 9 respectively; the second part has 2 digits, 7 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 34329-73:
(7*3)+(6*4)+(5*3)+(4*2)+(3*9)+(2*7)+(1*3)=112
112 % 10 = 2
So 34329-73-2 is a valid CAS Registry Number.
34329-73-2Relevant articles and documents
Analogs of phosphoenolpyruvate. Specificity of pyruvate kinase from rabbit muscle.
Stubbe,Kenyon
, p. 2669,2670 (1971)
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Synthesis and evaluation of a novel series of 2,7-substituted-6-tetrazolyl-1,2,3,4-tetrahydroisoquinoline derivatives as selective peroxisome proliferator-activated receptor γ partial agonists
Morishita, Ko,Ito, Yuma,Otake, Kazuya,Takahashi, Kenji,Yamamoto, Megumi,Kitao, Tatsuya,Ozawa, Shin-Ichiro,Hirono, Shuichi,Shirahase, Hiroaki
, p. 333 - 351 (2021/04/30)
A novel series of 7-substituted-2-[3-(2-furyl)acryloyl]-6-tetrazolyl-1,2,3,4-tetrahydroisoquinoline derivatives were synthesized to clarify structure–activity relationships for peroxisome proliferator-activated receptor γ (PPARγ) partial agonist activity
HETEROCYCLIC COMPOUNDS AS PRMT5 INHIBITORS
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Paragraph 000220, (2019/06/11)
The compounds of Formula I, Formula Ia, and Formula Ib are described herein along with their analogs, tautomeric forms, stereoisomers, polymorphs, hydrates, solvates, pharmaceutically acceptable salts, pharmaceutical compositions, metabolites, and prodrugs thereof. These compounds inhibit PRMT5 and are useful as therpeautic or ameliorating agent for diseases that are involved in cellular growth such as malignant tumors, schizophrenia, Alzheimer's disease, Parkinson's disease and the like.
