343306-79-6

Basic information

• Product Name: Sugammadex sodium
• Synonyms: ORG-25969/SugaMMadex;Sugammadex Na;Sugammadex IMP;Sugammadex soidum 343306-79-6;Sugammadex sodium iMpurity;6A,6B,6C,6D,6E,6F,6G,6H-octakis-S-(2-Carboxyethyl)-6A,6B,6C,6D,6E,6F,6G,6H-octathio-γ-cyclodextrin Sodium Salt;Sugammadex Sodium salt;6A,6B,6C,6D,6E,6F,6G,6H-Octakis-S-(2-carboxyethyl)-6A,6B,6C,6D,6E,6F,6G-octasulfanyl-gamma-cyclodextrin octasodium salt
• CAS NO: 343306-79-6
• Molecular Formula: C72H104Na8O48S8
• Molecular Weight: 2177.97
• Mol File: 343306-79-6.mol
• Article Data: 0

Chemical Properties

• Appearance: /
• Storage Temp.: Inert atmosphere,Room Temperature
• CAS DataBase Reference: Sugammadex sodium(CAS DataBase Reference)
• NIST Chemistry Reference: Sugammadex sodium(343306-79-6)
• EPA Substance Registry System: Sugammadex sodium(343306-79-6)

Safety Data

• Hazardous Substances Data: 343306-79-6(Hazardous Substances Data)

Usage

Description

To facilitate tracheal intubation, mechanical ventilation, and surgical access, NMB agents are frequently used as non-anesthetic adjuncts in surgical procedures. Sugammadex is able to function as a pharmacologic sink of rocuronium and vecuronium, another non-depolarizing neuromuscular blocker, without the cardiovascular adverse effects experienced with reversal agents that directly interact with the cholinergic system. The γ-cyclodextrin has been designed to enhance binding of the guest by incorporating acidic side chains to promote an electrostatic interaction with the positive nitrogen of the blocker. Starting with γ-cyclodextrin, these side chains are readily installed by first halogenating with iodine or bromine to provide a handle for nucleophilic displacement with either 3-mercaptopropionic acid in the presence of sodium hydride or with 3-mercaptopropionic acid methyl ester and cesium carbonate. The latter requires hydrolysis with sodium hydroxide to generate sugammadex sodium.

Chemical Properties

White to Light yellow powder to crystal.Soluble in water, insoluble in methanol and ethanol.

Originator

Organon (Netherlands)

Uses

Sugammadex Sodium is the first in a class of drugs called selective relaxant binding agents that offers improved termination of the paralytic effects of neuromuscular blocking agents and may have many potential peri-operative benefits.

Definition

ChEBI: An organic sodium salt that is the octasodium salt of sugammadex. Used for reversal of neuromuscular blockade induced by rocuronium and vecuronium in adults undergoing surgery.

Application

Sugammadex sodium is a modified γ-cyclodextrin. It is a selective relaxant binding agent (SRBA) indicated for reversal of neuromuscular block induced by steroid-based muscle relaxants, such as rocuronium bromide and vecuronium bromide. Sugammadex soium forms a complex with the muscle relaxants, and it reduces the amount of them available to bind to nicotinic cholinergic receptors in the neuromuscular junction.

Brand name

Bridion

Side effects

The most common adverse effects included coughing, movement, vomiting, dry mouth, dysgeusia, hypotension, parosmia, and a sensation of changed temperature.Sugammadex is recommended for the reversal of neuromuscular blockade induced by rocuronium or vecuronium; it should not be used with other steroidal blocking agents since safety and efficacy data are not available for these situations. It should also not be partnered with non-steroidal neuromuscular blockers such as succinylcholine or benzylisoquinolinium-based drugs. Since sugammadex is predominantly cleared by the kidneys, care should be taken when administering this reversal agent in patients with renal impairment.