34352-59-5

Basic information

• Product Name: 1-METHYLPIPERAZINE DIHYDROCHLORIDE
• Synonyms: 1-Methylpiperazine2HCl;1-METHYLPIPERAZINE DIHYDROCHLORIDE 98%;1-Methylpiperazine dihydrochloride,98%;N-Methyl piperazine hydrochloride;1-METHYLPIPERAZINE D;TIMTEC-BB SBB003822;1-METHYLPIPERAZINE DIHYDROCHLORIDE
• CAS NO: 34352-59-5
• Molecular Formula: C₅H₁₄N₂*2Cl
• Molecular Weight: 173.08
• Product Categories: Building Blocks;Heterocyclic Building Blocks;Piperazines;Building Blocks;C4 to C8;Chemical Synthesis;Heterocyclic Building Blocks
• Mol File: 34352-59-5.mol
• Article Data: 8

Chemical Properties

• Melting Point: 246-250 °C(lit.)
• Boiling Point: 138 °C at 760 mmHg
• Flash Point: 42.2 °C
• Appearance: White to off-white/Powder
• Vapor Pressure: 6.86mmHg at 25°C
• Storage Temp.: Refrigerator
• Solubility: 1 M NH4OH: soluble25mg/mL, clear to hazy, colorless to light yel
• CAS DataBase Reference: 1-METHYLPIPERAZINE DIHYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-METHYLPIPERAZINE DIHYDROCHLORIDE(34352-59-5)
• EPA Substance Registry System: 1-METHYLPIPERAZINE DIHYDROCHLORIDE(34352-59-5)

Safety Data

• Hazard Codes: T
• Statements: 23/24/25-36/37/38
• Safety Statements: 26-28-36/37/39-45
• WGK Germany: 3
• Hazardous Substances Data: 34352-59-5(Hazardous Substances Data)

Usage

Chemical Properties

off-white to light yellow powder

Uses

Different sources of media describe the Uses of 34352-59-5 differently. You can refer to the following data:
1. 1-Methylpiperazine dihydrochloride is used in the preparation of 2-(4-Methyl-1-piperazinylmethyl)acrylophenone(MPMAP).
2. 1-Methylpiperazine is used in the preparation of 2-(4-Methyl-1-piperazinylmethyl)acrylophenone(MPMAP), an antimicrotubular drug.
3. 1-Methylpiperazine dihydrochloride (Methylpiperazine dihydrochloride) has been used in the preparation of 1-methylpiperazine-1,4-diium tetrachloridozincate hemihydrate.

InChI:InChI=1/C5H12N2.2ClH/c1-7-4-2-6-3-5-7;;/h6H,2-5H2,1H3;2*1H

Upstream product

• 2055-46-1 3,4,5,6-tetrahydropyrimidine-2-thione 
• 42951-91-7 2-chloro-1-(4-methylpiperazin-1-yl)ethan-1-one hydrochloride 
• 62226-74-8 1-benzyl-4-methylpiperazine 
• 109-01-3 1-methyl-piperazine 
• 5625-52-5 1-methylpiperazin-2,5-dione 
• 7647-01-0 hydrogenchloride 
• 93378-54-2 1-methyl-4-(2-tetrahydro-1,3-diazepinylthioacetyl)piperazine dihydrochloride 
• 93378-52-0 1-methyl-4-(2-tetrahydropyrimidinylthioacetyl)piperazine dihydrochloride 

Downstream Products

• 60868-01-1 3-(4-methylpiperazin-1-yl)-1-phenylpropan-1-one 
• 100316-89-0 3-(4-methyl-piperazino)-1-[2]thienyl-propan-1-one 
• 132502-06-8 1-[2-(2-benzyl-phenoxy)-ethyl]-4-methyl-piperazine 
• 33860-28-5 4-methylpiperazine-1-carbothioamide 
• 75956-17-1 2-Methyl-6-[2-(4-methyl-piperazin-1-yl)-ethyl]-4-o-tolyl-1,4-dihydro-pyridine-3,5-dicarboxylic acid diethyl ester 
• 13993-24-3 1,4-bis(2-benzoylethyl)piperazine 
• 93546-62-4 N⁵-(5-phenyl-1,3,4-oxadiazol-2-ylaminocarbonyl)-4-methyl-1-piperazinobiguanide 
• 93546-63-5 N-{Imino-[3-(5-p-tolyl-[1,3,4]oxadiazol-2-yl)-ureido]-methyl}-4-methyl-piperazine-1-carboxamidine 
• 93546-64-6 N-(Imino-{3-[5-(4-methoxy-phenyl)-[1,3,4]oxadiazol-2-yl]-ureido}-methyl)-4-methyl-piperazine-1-carboxamidine 
• 93546-65-7 N-({3-[5-(4-Dimethylamino-phenyl)-[1,3,4]oxadiazol-2-yl]-ureido}-imino-methyl)-4-methyl-piperazine-1-carboxamidine 
• 93546-66-8 N-(Imino-{3-[5-(4-nitro-phenyl)-[1,3,4]oxadiazol-2-yl]-ureido}-methyl)-4-methyl-piperazine-1-carboxamidine 
• 93546-50-0 N-{Imino-[3-(4-phenyl-5-phenylazo-thiazol-2-yl)-ureido]-methyl}-4-methyl-piperazine-1-carboxamidine 
• 93546-53-3 N-({3-[4-(4-Chloro-phenyl)-5-phenylazo-thiazol-2-yl]-ureido}-imino-methyl)-4-methyl-piperazine-1-carboxamidine 
• 93546-51-1 N-{Imino-[3-(4-phenyl-5-p-tolylazo-thiazol-2-yl)-ureido]-methyl}-4-methyl-piperazine-1-carboxamidine 

Relevant articles and documents

Highly chemoselective Pd-C catalytic hydrodechlorination leading to the highly efficient N-debenzylation of benzylamines

(Equation Presented) In the presence of 1,1,2-trichloroethane, a novel procedure for the Pd-C catalytic N-debenzylation of benzylamines was established. The method proceeded in a synergistic catalytic system and directly gave the products as crystal amine hydrochlorides in practically quantitative yields.

Modular syntheses of multidentate ligands with variable N-donors: Applications to tri- and tetracopper(i) complexes

A general method for the preparation of multidentate ligands comprised of a multi-imine platform derived from 1,1,1-tris(aminomethyl)ethane or tris(aminoethyl)amine connected to bi- and tridentate N-donor chelates has been developed. The feasibility of the method has been demonstrated through the synthesis and characterization of a large set of these ligand types. Complexation to Cu(i) was accomplished for several cases, yielding tri- and tetracopper(i) complexes that have been characterized in solution by NMR spectroscopy and conductivity, and in the solid state by elemental analysis, mass spectrometry, and/or X-ray crystallography. These complexes are potentially useful for modeling multicopper protein active sites. The Royal Society of Chemistry.

Isotopically enriched N-substituted piperazines and methods for the preparation thereof

In some embodiments, this invention pertains to isotopically enriched N-substituted piperazines. In some embodiments, this invention pertains to methods for the preparation of isotopically enriched N-substituted piperazines.