345294-39-5

Basic information

• Product Name: 1'-Benzylspiro[isochroMan-1,4'-piperidine]
• Synonyms: 1'-Benzylspiro[isochroMan-1,4'-piperidine]
• CAS NO: 345294-39-5
• Molecular Formula: C20H23NO
• Molecular Weight: 293.40272
• Mol File: 345294-39-5.mol
• Article Data: 4

Chemical Properties

• Melting Point: 50 °C
• Boiling Point: 429.3±45.0 °C(Predicted)
• Appearance: /
• Density: 1.14±0.1 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 8.56±0.20(Predicted)
• CAS DataBase Reference: 1'-Benzylspiro[isochroMan-1,4'-piperidine](CAS DataBase Reference)
• NIST Chemistry Reference: 1'-Benzylspiro[isochroMan-1,4'-piperidine](345294-39-5)
• EPA Substance Registry System: 1'-Benzylspiro[isochroMan-1,4'-piperidine](345294-39-5)

Safety Data

• Hazardous Substances Data: 345294-39-5(Hazardous Substances Data)

Usage

General Description

1'-Benzylspiro[isochroMan-1,4'-piperidine] is a chemical compound with a spiro ring structure consisting of a piperidine ring fused to an isochroman ring, with a benzyl group attached to the nitrogen atom of the piperidine ring. 1'-Benzylspiro[isochroMan-1,4'-piperidine] is a derivative of spirocyclic compounds, which have diverse pharmacological properties and potential therapeutic applications. The benzyl group attached to the piperidine ring imparts unique chemical and biological properties to this compound, making it a potential candidate for drug development. The structural features of 1'-Benzylspiro[isochroMan-1,4'-piperidine] make it an interesting target for further research and exploration in the field of medicinal chemistry.

Upstream product

• 3612-20-2 1-phenylmethyl-4-piperidone 
• 60-12-8 2-phenylethanol 
• 1226808-07-6 1-benzyl-4-[2-(2-hydroxy-ethyl)-phenyl]-piperidin-4-ol 
• 1074-15-3 1-bromo-2-(2-bromoethyl)benzene 

Downstream Products

• 180160-97-8 3,4-dihydrospiro[[2]benzopyran-1,4'-piperidine] 

Relevant articles and documents

Easy-To-Synthesize Spirocyclic Compounds Possess Remarkable in Vivo Activity against Mycobacterium tuberculosis

Society urgently needs new, effective medicines for the treatment of tuberculosis. To kick-start the required hit-to-lead campaigns, the libraries of pharmaceutical companies have recently been evaluated for starting points. The GlaxoSmithKline (GSK) library yielded many high-quality hits, and the associated data were placed in the public domain to stimulate engagement by the wider community. One such series, the spiro compounds, are described here. The compounds were explored by a combination of traditional in-house research and open source methods. The series benefits from a particularly simple structure and a short associated synthetic chemistry route. Many members of the series displayed striking potency and low toxicity, and highly promising in vivo activity in a mouse model was confirmed with one of the analogues. Ultimately the series was discontinued due to concerns over safety, but the associated data remain public domain, empowering others to resume the series if the perceived deficiencies can be overcome.

Novel spiropiperidines as highly potent and subtype selective σ-receptor ligands. Part 1

A series of spiro[[2]benzopyran-1,4′-piperidines] and spiro[[2]benzofuran-1,4′-piperidines] of general structure 10 is prepared, and the affinity for σ1- and σ2-receptors is investigated by means of radioligand binding assays. The sy