345311-09-3

Basic information

• Product Name: 5,6,7,8-TETRAHYDRO-[1,2,4]TRIAZOLO[4,3-A]PYRAZINE HYDROCHLORIDE
• Synonyms: 5,6,7,8-TETRAHYDRO-[1,2,4]TRIAZOLO[4,3-A]PYRAZINE HYDROCHLORIDE;1,2,4-Triazolo[4,3-a]pyrazine,5,6,7,8-tetrahydro-(9CI);5,6,7,8-Tetrahydro-[1,2,4]triazolo[4,3-A]pyrazine ,97%;5,6,7,8-tetrahydro-[1,2,4...;1,2,4-Triazolo[4,3-a]pyrazine, 5,6,7,8-tetrahydro-;5,6,7,8-TETRAHYDRO-1,2,4-TRIAZOLO[4,3-A]PYRAZINE (HCl forM);5,6,7,8-Tetrahydro[1,2,4]triazolo[4,3-a]pyrazine hydrochloride (1:1)
• CAS NO: 345311-09-3
• Molecular Formula: C5H9ClN4
• Molecular Weight: 160.6
• Product Categories: AMINETERTIARY;Thiazole;API intermediates;CHIRAL CHEMICALS
• Mol File: 345311-09-3.mol
• Article Data: 5

Chemical Properties

• Boiling Point: 319.763 °C at 760 mmHg
• Flash Point: 147.187 °C
• Appearance: white powder
• Density: 1.539 g/cm³
• PKA: 6.05±0.20(Predicted)
• CAS DataBase Reference: 5,6,7,8-TETRAHYDRO-[1,2,4]TRIAZOLO[4,3-A]PYRAZINE HYDROCHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 5,6,7,8-TETRAHYDRO-[1,2,4]TRIAZOLO[4,3-A]PYRAZINE HYDROCHLORIDE(345311-09-3)
• EPA Substance Registry System: 5,6,7,8-TETRAHYDRO-[1,2,4]TRIAZOLO[4,3-A]PYRAZINE HYDROCHLORIDE(345311-09-3)

Safety Data

• Hazard Codes: T
• Statements: 25
• Safety Statements: 45
• HazardClass: IRRITANT
• Hazardous Substances Data: 345311-09-3(Hazardous Substances Data)

Usage

General Description

5,6,7,8-Tetrahydro-[1,2,4]triazolo[4,3-a]pyrazine hydrochloride is a chemical compound with the molecular formula C3H6N4 HCl. It is a hydrazine derivative and a pyrazine analog that is used in research and pharmaceutical applications. 5,6,7,8-TETRAHYDRO-[1,2,4]TRIAZOLO[4,3-A]PYRAZINE HYDROCHLORIDE has been studied for its potential effects in the central nervous system and has been investigated for potential use in the treatment of conditions such as anxiety and depression. It is important to handle and use this compound with care, following all safety guidelines and regulations for handling hazardous chemicals.

Upstream product

• 68774-77-6 8-chloro-[1,2,4]triazolo[4,3-a]pyrazine 
• 274-82-8 [1,2,4]triazolo[4,3-a]pyrazine 

Downstream Products

• 1438074-81-7 N-(4-bromo-2-fluorophenyl)-6-(3-(5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)propoxy)-7-methoxyquinazolin-4-amine 
• 1438074-45-3 6-(3-(5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)propoxy)-N-(3-ethynyl-4-fluorophenyl)-7-methoxyquinazolin-4-amine 
• 1438074-63-5 6-(3-(5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)propoxy)-N-(3-ethynylphenyl)-7-methoxyquinazolin-4-amine 
• 1438074-28-2 6-(3-(5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)propoxy)-N-(4-fluorophenyl)-7-methoxyquinazolin-4-amine 
• 1438072-05-9 N-(3-chloro-4-fluorophenyl)-6-(3-(5.6-dihydro-[1,2,4]triazolo[4.3-a]pyrazin-7(8H)-yl)propoxy)-7-methoxyquinazolin-4-amine 
• 723286-81-5 7-(tert-butoxycarbonyl)-3-methoxy-5,6,7,8-tetrahydro[1,2,4]triazolo[3,4-a]pyrazine 
• 723286-80-4 3-bromo-5,6-dihydro-8H-[1,2,4]triazolo[4,3-a]pyrazine-7-carboxylic acid tert-butyl ester 
• 1429181-28-1 (S)-tert-butyl 1-(4-((5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazin-7(8H)-yl)methyl)phenyl)ethylcarbamate 
• 723286-79-1 tert-butyl 5,6-dihydro-[1,2,4]triazolo[4,3-a]pyrazine-7(8H)-carboxylate 

Relevant articles and documents

PYRIMIDO[5,4-d]PYRIMIDINE DERIVATIVES AS ENT INHIBITORS FOR THE TREATMENT OF CANCERS, AND COMBINATION THEREOF WITH ADENOSINE RECEPTOR ANTAGONISTS

The present invention relates to pyrimido[5,4-d]pyrimidine derivatives of formula (I), including pharmaceutically acceptable salts and solvates thereof. Compounds of the invention are inhibitors of ENT family transporter, especially of ENT1, and are useful as therapeutic compounds for the treatment of cancers. The invention also relates to the combined use of the pyrimido[5,4-d]pyrimidine derivatives with an adenosine receptor antagonist, for the treatment of cancers.

AMINOQUINAZOLINE DERIVATIVES AND THEIR SALTS AND METHODS OF USE

The present invention relates to the field of medicine. Provided herein are aminoquinazoline derivatives, their salts and pharmaceutical formulations useful in modulating the protein tyrosine kinase activity, and in modulating inter- and/or intra-cellular signaling. Also provided herein are pharmaceutically acceptable compositions comprising the aminoquinazoline compounds and methods of using the compositions in the treatment of hyperproliferative disorders in mammals, especially humans.

3-AMINO-4-PHENYLBUTANOIC ACID DERIVATIVES AS DIPEPTIDYL PEPTIDASE INHIBITORS FOR THE TREATMENT OR PREVENTION OF DIABETES

The present invention is directed to 3-amino-4-phenylbutanoic acid derivatives which are inhibitors of the dipeptidyl peptidase-IV enzyme ("DP-IV inhibitors") and which are useful in the treatment or prevention of diseases in which the dipeptidyl peptidase-IV enzyme is involved, such as diabetes and particularly type 2 diabetes. The invention is also directed to pharmaceutical compositions comprising these compounds and the use of these compounds and compositions in the prevention or treatment of such diseases in which the dipeptidyl peptidase-IV enzyme is involved.