34581-21-0

Basic information

• Product Name: 1-(2-BUTYL)-PIPERAZINE
• Synonyms: 1-(sec-Butyl)piperazine, 2-(Piperazin-1-yl)butane;RARECHEM AH CK 0064;TIMTEC-BB SBB007161;AKOS BB-5482;AKOS B023078;1-(2-BUTYL)-PIPERAZINE;1-SEC-BUTYL-PIPERAZINE;ART-CHEM-BB B023078
• CAS NO: 34581-21-0
• Molecular Formula: C₈H₁₈N₂
• Molecular Weight: 142.24
• Product Categories: Piperaizine;piperazines
• Mol File: 34581-21-0.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 189.6 °C at 760 mmHg
• Flash Point: 61.3 °C
• Appearance: /
• Density: 0.877 g/cm³
• Vapor Pressure: 0.564mmHg at 25°C
• Refractive Index: 1.453
• PKA: 9.27±0.10(Predicted)
• CAS DataBase Reference: 1-(2-BUTYL)-PIPERAZINE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-BUTYL)-PIPERAZINE(34581-21-0)
• EPA Substance Registry System: 1-(2-BUTYL)-PIPERAZINE(34581-21-0)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 22
• Hazardous Substances Data: 34581-21-0(Hazardous Substances Data)

Usage

General Description

1-(2-butyl)-piperazine is a chemical compound that belongs to the class of piperazine derivatives. It is a liquid with a molecular formula of C8H18N2 and a molecular weight of 142.24 g/mol. 1-(2-BUTYL)-PIPERAZINE is used in various industrial applications, including as a corrosion inhibitor, a pharmaceutical intermediate, and in the synthesis of organic compounds. It is also used in the manufacture of agrochemicals and as a reagent in chemical research. Additionally, 1-(2-butyl)-piperazine is known to have biological activity, making it a potential candidate for pharmaceutical development.

InChI:InChI=1/C8H18N2/c1-3-8(2)10-6-4-9-5-7-10/h8-9H,3-7H2,1-2H3

Upstream product

• 110-85-0 piperazine 
• 78-76-2 s-butyl bromide 

Downstream Products

• 185547-07-3 (4-sec-Butyl-piperazin-1-yl)-(4-hydroxy-phenyl)-methanone 
• 1026344-22-8 Acetic acid 4-(4-sec-butyl-piperazine-1-carbonyl)-phenyl ester 

Relevant articles and documents

Pyridinecarboxamide derivatives

Pyridinecarboxamide derivatives of the formula STR1 (wherein n represents an integer of 14-18, and R represents a hydrogen atom or a straight or branched C1 -C4 alkyl group) or physiologically acceptable salts thereof. The compounds have excellent inhibiting activity of cerebral edema, especially ischemic cerebral edema, and inhibiting activity of delayed death of neuronal cells (an inhibiting activity of Ca-influx in neuronal cells). Cerebral edema is a pathologic condition accompanying cerebrovascular disorders, especially the acute stage of cerebrovascular disorders and then the compounds are useful as an agent for inhibiting cerebral edema or a therapeutic agent for cerebrovascular disorders. Moreover, the compounds have no hypotensive action which is considered to be side-effect in treating the acute stage cerebrovascular disorders and hardly show a behavior suppressing action so that they are an excellent therapeutic agent for, in particular, the acute stage cerebrovascular disorders. Moreover, the compounds show a cerebral protective activity (an anti-anoxic activity), an increasing activity of cerebral blood flow, and an inhibiting activity of lipid peroxidation and these activities may lead to the increased utility as a therapeutic agent for cerebrovascular disorders.

Ruthenium catalyzed reactions of ethylene glycol with primary amines: steric factors and selectivity control

The selectivity of reactions of ethylene glycol with primary amines in the presence of RuCl2(PPh3)3 at 120 deg C is highly dependent on the steric nature of the amine.Selectivity to di-amination is favored by smaller alkyl groups on the amine while large amines cleanly yield ethanolamines.This contrasts with the results obtained with secondary amines at this temperature, in which ruthenium-triphenylphosphine catalyst systems always favor mono-amination.In the case of sec-butyl amine, where almost equal amounts of mono- and di-aminated product are obtained, the selecti vity can be shifted to mono-amination by the addition of excess triphenylphosphine.The steric effects seen in these reactions are consistent with standard steric parameters availble from the literature.