34595-91-0

Basic information

• Product Name: 2,3,5-TriMethyl-6-broMopyridine
• Synonyms: 2,3,5-TriMethyl-6-broMopyridine;2-Bromo-3,5,6-trimethylpyridine
• CAS NO: 34595-91-0
• Molecular Formula: C8H10BrN
• Molecular Weight: 200
• Mol File: 34595-91-0.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 255.212 °C at 760 mmHg
• Flash Point: 108.149 °C
• Appearance: /
• Density: 1.355 g/cm³
• Refractive Index: 1.542
• CAS DataBase Reference: 2,3,5-TriMethyl-6-broMopyridine(CAS DataBase Reference)
• NIST Chemistry Reference: 2,3,5-TriMethyl-6-broMopyridine(34595-91-0)
• EPA Substance Registry System: 2,3,5-TriMethyl-6-broMopyridine(34595-91-0)

Safety Data

• Hazardous Substances Data: 34595-91-0(Hazardous Substances Data)

Usage

General Description

2,3,5-Trimethyl-6-bromopyridine is a chemical compound with the molecular formula C8H10BrN. It is a derivative of pyridine and is classified as a brominated heterocyclic compound. This chemical is commonly used in organic synthesis and pharmaceutical research as a building block for the synthesis of various biologically active molecules. Its unique structure and reactivity make it valuable in the development of new drugs and agrochemicals. Additionally, 2,3,5-Trimethyl-6-bromopyridine is also used in the production of fine chemicals and specialty materials for a variety of industrial applications. However, it is important to handle this chemical with care, as it may pose health and environmental hazards if not properly managed.

InChI:InChI=1/C8H10BrN/c1-5-4-6(2)8(9)10-7(5)3/h4H,1-3H3

Upstream product

• 56705-18-1 2-Amino-3,5,6-trimethylpyridine 
• 917-54-4 methyllithium 
• 117846-58-9 2,6-dibromo-3,5-dimethylpyridine 

Relevant articles and documents

IMIDAZOPYRIDINE DERIVATIVES AS ALPHA4BETA7 INTEGRIN INHIBITORS

The present disclosure provides a compound of Formula (I): or a pharmaceutically acceptable salt thereof as described herein. The present disclosure also provides pharmaceutical compositions comprising a compound of Formula (I), processes for preparing co

Synthetic method of 2,3,5-trimethyl-6-bromopyridine

The invention relates to the field of organic chemistry, in particular to a synthetic method of 2,3,5-trimethyl-6-bromopyridine. The synthetic method comprises the following steps: enabling diethyl malonate to react with alkali metal to generate salt, dropwise adding a toluene solution of 2,3-dimethyl-6-nitro-5-chloropyridine for condensation reaction and then decarboxylating under an acidic condition to obtain 2,3,5-trimethyl-6-nitropyridine; performing hydrogenation reduction on the 2,3,5-trimethyl-6-nitropyridine by taking methanol as a solvent under Pd/C catalysis, performing suction filtration and concentrating a filtrate to obtain 2,3,5-trimethyl-6-aminopyridine; enabling the 2,3,5-trimethyl-6-aminopyridine and acid to generate salt, cooling to 9 DEG C below zero to 4 DEG C, dropwise adding liquid bromine, dropwise adding a sodium nitrite aqueous solution after the completion of dropwise adding, regulating the pH of the solution to be alkaline after the completion of dropwise adding, extracting, drying and concentrating to obtain the 2,3,5-trimethyl-6-bromopyridine. The synthetic method provided by the invention has the benefits of being mild in reaction condition, high in yield, readily-available in raw material, lower in cost and short in process route and has industrial prospect.