346-34-9

Basic information

• Product Name: 4-Fluoroindoline-2,3-dione
• Synonyms: 4-FLUOROINDOLINE-2,3-DIONE;4-Fluoroisatin;4-FLUOROINDOLINC-2,3-DIONC;4-Fluoro-1H-indole-2,3-dione;4-fluoro-2,3-dihydro-1H-indole-2,3-dione;1H-Indole-2,3-dione,4-fluoro-
• CAS NO: 346-34-9
• Molecular Formula: C₈H₄FNO₂
• Molecular Weight: 165.1212632
• EINECS: 1533716-785-6
• Product Categories: Heterocyclic Compounds
• Mol File: 346-34-9.mol
• Article Data: 8

Chemical Properties

• Appearance: /
• Density: 1.477
• Refractive Index: 1.584
• Storage Temp.: Sealed in dry,Room Temperature
• PKA: 8.56±0.20(Predicted)
• CAS DataBase Reference: 4-Fluoroindoline-2,3-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Fluoroindoline-2,3-dione(346-34-9)
• EPA Substance Registry System: 4-Fluoroindoline-2,3-dione(346-34-9)

Safety Data

• Hazardous Substances Data: 346-34-9(Hazardous Substances Data)

Usage

General Description

4-Fluoroindoline-2,3-dione, also known as 4-Fluoroisatin, is an organic compound. This chemical compound belongs to the family of Indolines and is characterized by its two oxygen-containing functional groups and a fluorine atom, making it a fluorinated compound. It typically appears as a fine, slightly yellow or pale pink crystalline powder. Notable for its use in the synthesis of various chemical substances, it is a useful intermediate in organic chemistry for the production of pharmaceuticals, agrochemicals, and dyes. Its hazards and environmental effects, however, are not fully documented and thus should be handled with caution.

InChI:InChI=1/C8H4FNO2/c9-4-2-1-3-5-6(4)7(11)8(12)10-5/h1-3H,(H,10,11,12)

Upstream product

• 372-19-0 meta-fluoroaniline 
• 302-17-0 chloral hydrate 
• 344790-94-9 1-(2-(2-fluoro-6-nitrophenyl)vinyl)pyrrolidine 
• 387-43-9 4-fluoroindole 
• 769-10-8 1-fluoro-2-methyl-3-nitrobenzene 
• 350-78-7 3-fluoro-isonitrosoacetanilide 
• 350-78-7 (2E)-N-(3-fluorophenyl)-2-hydroxyiminoacetamide 

Downstream Products

• 1219834-23-7 C₁₀H₆FNO₂ 

Relevant articles and documents

Industrial preparation method of high-purity 4-fluoroisatin

The invention discloses an industrial preparation method of high-purity 4-fluoroisatin. The preparation method comprises the steps: firstly, reacting m-fluoroaniline with hydroxylamine hydrochloride and trichloracetic aldehyde, and carrying out condensation to prepare oximide acetanilide; then, cyclizing concentrated sulphuric acid, and carrying out hydrolysis to prepare a mixture of 4-fluoroisatin and 6-fluoroisatin; and then, separating and purifying the mixture of 4-fluoroisatin and 6-fluoroisatin by using an alkali solution acidolysis method to obtain high-purity 4-fluoroisatin. The industrial preparation method is simple in process, high in yield, low in production cost and suitable for industrial production.

METHOD FOR PRODUCING 4-FLUOROISATIN DERIVATIVE

PROBLEM TO BE SOLVED: To provide a method for producing a 4-fluoroisatin derivative including 4-fluoroisatin at high purity and at high yield. SOLUTION: Provided is a method for producing a 4-fluoroisatin, in a production process of a 4-fluoroisatin derivative represented by general formula (1), comprising: a step (A) where a toluene derivative represented by the general formula (2) is used as starting raw material, the toluene derivative is carbon-increased using DMFdialkylacetal, and thereafter, reduction is performed using a reducing agent and acid to synthesize an indol derivative represented by general formula (3); and a step (B) where the indol derivative is oxidized. SELECTED DRAWING: None COPYRIGHT: (C)2017,JPOandINPIT

Novel synthesis of 4-or 6-substituted indirubin derivatives

A simple and convenient route for synthesis of a series of 4-or 6-substituted indirubin derivatives by oxidation and subsequent condensation of indoxyl and isatin is described. Acidic reaction conditions are crucial to the condensation of 4-substituted derivatives, whereas for the condensation of 6-substituted derivatives, both acidic and basic conditions work well. Copyright Taylor & Francis Group, LLC.