34611-43-3Relevant articles and documents
Synthesis and crystal structure of bis-chalcone-derived fused-ring pyrazoline having an unusual substitution pattern
Ashraf, Shumaila,Hameed, Shahid,Tahir, Muhammad Nawaz,Naseer, Muhammad Moazzam
, p. 1871 - 1875 (2017)
Abstract: Pyrazolines are an important class of heterocyclic compounds with diverse applications. A novel bis-chalcone-derived fused ring pyrazoline has been obtained by the reaction of bis-chalcone with hydrazine hydrate in acetic acid solvent having a catalytic amount of HCl and characterized by IR, 1H and 13C NMR, GC–MS, and finally by X-ray single crystal analysis. Interestingly, the in situ post-cyclization substitution pattern on pyrazoline ring nitrogen is entirely different from the previously reported related pyrazoline derivatives. The new compound crystallizes out from its ethanolic solution, which has monoclinic crystal lattice with P21/c space group, a?=?6.1001(4)??, b?=?38.602(2)??, c?=?7.7332(5)??, α?=?90°, β?=?113.039(3)°, γ?=?90°, V?=?1675.73(19)??3, Z?=?4, crystal size?=?0.38?×?0.30?×?0.18?mm3, and Rint?=?0.043. Graphical abstract: [Figure not available: see fulltext.].
Application of monocarbonyl curcumin compound in preparation of medicine for preventing and treating periodontitis
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Paragraph 0024-0026, (2021/06/22)
The invention belongs to the technical field of medicines, and particularly relates to application of a specific monocarbonyl curcumin analogue in preparation of a medicine for preventing and treating periodontitis. Experiments prove that the monocarbonyl curcumin analogues not only can play a better anti-oxidation protection role by activating an Nrf2/HO-1 signal channel, but also can play an anti-inflammatory role by inhibiting release of inflammatory factors TNF alpha and IL1-beta, so that the monocarbonyl curcumin analogues have a remarkable prevention and treatment effect on rat periodontitis, have good potential value and significance for prevention and treatment of periodontitis, and have a good research and development prospect.
Corrosion study of copper in aqueous sulfuric acid solution in the presence of (2E,5E)-2,5-dibenzylidenecyclopentanone and (2E,5E)-bis[(4-dimethylamino)benzylidene]cyclopentanone: Experimental and theoretical study
Tha?i, Veprim,Hoti, Ramiz,Berisha, Avni,Bogdanov, Jane
, p. 1412 - 1420 (2020/12/23)
The corrosion behavior of copper in 0.1 M aqueous sulfuric acid medium has been studied using potentiodynamic polarization measurements, quantum chemical calculations, and molecular dynamic simulations in the presence and absence of (2E,5E)-2,5-dibenzylidenecyclopentanone (M1) and (2E,5E)-bis[(4-dimethylamino)benzylidene]cyclopentanone (M2). The compounds were freshly prepared in high yields via the Claisen-Schmidt reaction between the cyclopentanone and the corresponding aryl aldehyde. The results from the potentiodynamic measurements imply that M1 and M2 act as mixed inhibitors due to their adsorption on the copper surface. The more pronounced corrosion inhibition performance of the M2 molecule in comparison to M1 was related to the fact that this molecule contains two basic nitrogen atoms (in 4-dimethylamino group).