34632-04-7

Basic information

• Product Name: L-Cephalexin
• Synonyms: 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[(aminophenylacetyl)amino]-3-methyl-8-oxo-, [6R-[6α,7β(S*)]]-;5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2S)-aminophenylacetyl]amino]-3-methyl-8-oxo-, (6R,7R)-;7-(α-Amino-L-phenylacetamido)-3-deacetoxycephalosporanic acid;L-Cephalexin;(6R,7R)-7-[[(2S)-2-aMino-2-phenylacetyl]aMino]-3-Methyl-8-oxo-5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid;[6R-[6α,7β(S*)]]-7-[(AMinophenylacetyl)aMino]- 3-Methyl-8-oxo-5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid;7-(α-AMi;Cefalexin impurity L
• CAS NO: 34632-04-7
• Molecular Formula: C₁₆H₁₇N₃O₄S
• Molecular Weight: 347.39
• Product Categories: Amines;Chiral Reagents;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Sulfur & Selenium Compounds
• Mol File: 34632-04-7.mol
• Article Data: 24

Chemical Properties

• Appearance: /
• Storage Temp.: Hygroscopic, -20°C Freezer, Under inert atmosphere
• Solubility: Aqueous Acid (Slightly), DMSO (Slightly, Heated)
• Stability: Hygroscopic
• CAS DataBase Reference: L-Cephalexin(CAS DataBase Reference)
• NIST Chemistry Reference: L-Cephalexin(34632-04-7)
• EPA Substance Registry System: L-Cephalexin(34632-04-7)

Safety Data

• Hazardous Substances Data: 34632-04-7(Hazardous Substances Data)

Usage

Uses

Different sources of media describe the Uses of 34632-04-7 differently. You can refer to the following data:
1. The L-diastereomer of the β-lactam antibiotic Cephalexin (C256800). It is is transported by PEPT1 (the oligopeptide transporter responsible for absorption of peptide nutrients in the small intestine) with high affinity, but is not metabolized by PEPT1 itself.
2. The L-diastereomer of the β-lactam antibiotic Cephalexin (C256800). It is transported by PEPT1 (the oligopeptide transporter responsible for absorption of peptide nutrients in the small intestine) with high affinity, but is not metabolized by PEPT1 itself.

Upstream product

• 2900-27-8 (2S)-2-[(tert-butoxycarbonyl)amino]-2-phenylethanoic acid 
• 31461-05-9 (6R)-3-methyl-8-oxo-7t-(trimethylsilanyl-amino)-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid trimethylsilanyl ester 
• 33125-05-2 Boc-D-Phg-OH 
• 57872-59-0 (R)-2-(tert-butoxycarbonylamino)-2-(cyclohexa-1,4-dienyl)acetic acid 
• 24461-61-8 (R)-Phenylglycine methyl ester 
• 15690-38-7 (6R,7R)-7-amino-3-hydroxymethyl-8-oxo-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 
• 51795-31-4 (6R,7R)-7-amino-3-methylenecepham-4-carboxylic acid 
• 875-74-1 (R)-phenylglycine 
• 57872-62-5 N-tert-butyloxycarbonylcefradine 
• 34959-72-3 (6R,7R,4'R)-7-(2',2'-dimethyl-3'-nitroso-5'-oxo-4'-phenylimidazolidin-1'-yl)-3-methylceph-3-em-4-carboxylate 
• 28180-91-8 (6R)-7t-((R)-2-amino-2-phenyl-acetylamino)-3-methyl-8-oxo-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 2,2,2-trichloro-ethyl ester 
• 740029-13-4 (6R)-7t-((R)-2-amino-2-phenyl-acetylamino)-3-methylene-8-oxo-(6rH)-5-thia-1-aza-bicyclo[4.2.0]octane-2c-carboxylic acid 
• 2935-35-5 (S)-2-phenylglycine 
• 22252-43-3 3-deacetyloxy-7-aminocephalosporanic acid 

Downstream Products

• 28180-92-9 (6R,7R)-7-[(2R)-2-{[(tert-butoxy)carbonyl]amino}-2-phenylacetamido]-3-methyl-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid 
• 79750-46-2 (6R,7R)-3-methyl-7-[(R)-2-amino-2-phenylacetamido]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-3-ene-2-carboxylic acid 
• 15686-71-2 cefalexin 
• 34959-72-3 (6R,7R,4'R)-7-(2',2'-dimethyl-3'-nitroso-5'-oxo-4'-phenylimidazolidin-1'-yl)-3-methylceph-3-em-4-carboxylate 
• 109429-60-9 (6R,7R,4'S)-7-(2',2'-dimethyl-3'-nitroso-5'-oxo-4'-phenylimidazolidin-1'-yl)-3-methylceph-3-em-4-carboxylate 
• 36943-64-3 (6R)-7t-((R)-2,2-dimethyl-5-oxo-4-phenyl-imidazolidin-1-yl)-3-methyl-8-oxo-(6rH)-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 
• 22252-43-3 3-deacetyloxy-7-aminocephalosporanic acid 
• 875-74-1 (R)-phenylglycine 
• 82922-31-4 (6R,7R)-3-Methyl-8-oxo-7-[2-phenyl-2-(2-o-tolyl-isoureido)-acetylamino]-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 
• 82922-30-3 N-<(Amino-phenoxy)-methylen>cephalexin 

Relevant articles and documents

Preparation method of cefalexin

The invention belongs to the field of medicine synthesis, in particular to an improved method of a beta-lactam antibiotic cefalexin synthesis process. According to the method, 7-ADCA is used as a rawmaterial and is protected by carboxyl silane; after activation with alpha-aminophenylacetic acid hydrochloride and trifluoroacetic acid succinimide, condensation reaction is carried out; cefalexin isobtained through hydrolysis after-treatment, the proper pH value is controlled through hydrochloric acid after organic solvent and alkali adjustment treatment, and cefalexin crystals with extremely high purity are obtained. The method has the advantages of being easy and convenient to operate, mild in reaction condition, not prone to causing side reaction and capable of effectively removing impurities and preparing high-purity cefalexin.

MANUFACTURING METHOD AND APPARATUS OF ULTRAFINE PARTICLES HAVING UNIFORM PARTICLE SIZE DISTRIBUTION

The present invention relates to a novel technology for forming fine particles with a size of 0.02?3 microns from a solid that can be dissolved in a liquid solvent and is not decomposed by heat. The particle preparation technology according to the present invention may be applicable to the fields of food, cosmetics, biopolymer, polymer compositions, and pharmaceuticals.

Synthesis of cephalosporin-type antibiotics by coupling of their β-lactam nucleus and racemic amino acid side chains using a clathration-induced asymmetric transformation

The cephalosporin-type antibiotics Cephalexin, Cephradine and Cefadroxil have been prepared by coupling of their β-lactam nucleus and racemic amino acid side chain precursors. The initially obtained mixture of cephalosporin epimers is subjected to a clathration-induced asymmetric transformation which results in the epimerization of the epi-cephalosporin into the cephalosporin with the correct diastereomeric configuration.