346724-13-8

Basic information

• Product Name: 3-chloro-N-(2,4-dichlorophenyl)propanamide
• Synonyms: 3-chloro-N-(2,4-dichlorophenyl)propanamide;3-chloro-N-(2,4-dichlorophenyl)propionamide
• CAS NO: 346724-13-8
• Molecular Formula: C₉H₈Cl₃NO
• Molecular Weight: 252.52492
• Mol File: 346724-13-8.mol
• Article Data: 1

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 3-chloro-N-(2,4-dichlorophenyl)propanamide(CAS DataBase Reference)
• NIST Chemistry Reference: 3-chloro-N-(2,4-dichlorophenyl)propanamide(346724-13-8)
• EPA Substance Registry System: 3-chloro-N-(2,4-dichlorophenyl)propanamide(346724-13-8)

Safety Data

• HazardClass: IRRITANT
• Hazardous Substances Data: 346724-13-8(Hazardous Substances Data)

Upstream product

• 554-00-7 2,4-Dichloroaniline 
• 625-36-5 2-chloropropionyl chloride 

Relevant articles and documents

Synthesis, molecular docking studies, and absorption, distribution, metabolism, and excretion prediction of novel sulfonamide derivatives as antibacterial agents

A series of novel sulfonamide-amide derivatives were synthesized from 3-(2,4 dichlorophenylamino)-3-oxopropane-1-sulfonylchloride and a variety of amines under solvent-free conditions at room temperature. 3-(2,4-dichlorophenylamino)-3-oxopropane-1 sulfonylchloride was synthesized in four steps starting from 2,4-dichloroaniline and chloropropanoic acid in good yield and purity. The synthesized compounds were screened for their in vitro antibacterial activity against Escherichia coli (ATCC 25922) and Staphylococcus aureus (ATCC 29213). Molecular docking of sulfonamide derivatives into S. aureus tyrosyl-tRNA synthetase (TyrRS)-active site was also performed and among these, 5m and 5g tightly fit the active sites that might be inhibitors of TyrRS for further investigations. Also in the silico metabolism profile, drug-like properties and absorption, distribution, metabolism, excretion and toxicity (ADMET) of the title compounds were calculated by the preADMET server.