347186-49-6 Usage
General Description
2-(4-Boc-Piperazinyl)-2-phenylacetic acid is a chemical compound that is used in the pharmaceutical industry. It belongs to the group of acetic acid derivatives and contains a piperazine moiety with a tert-butoxycarbonyl (Boc) protecting group. 2-(4-Boc-Piperazinyl)-2-phenylacetic acid is known for its potential as a building block in the synthesis of various pharmaceuticals and bioactive molecules. It is also used as a reagent in organic chemistry reactions and has been studied for its potential pharmacological properties. Overall, 2-(4-Boc-Piperazinyl)-2-phenylacetic acid is an important intermediate in the synthesis of diverse compounds with potential therapeutic applications.
Check Digit Verification of cas no
The CAS Registry Mumber 347186-49-6 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 3,4,7,1,8 and 6 respectively; the second part has 2 digits, 4 and 9 respectively.
Calculate Digit Verification of CAS Registry Number 347186-49:
(8*3)+(7*4)+(6*7)+(5*1)+(4*8)+(3*6)+(2*4)+(1*9)=166
166 % 10 = 6
So 347186-49-6 is a valid CAS Registry Number.
InChI:InChI=1/C17H24N2O4/c1-17(2,3)23-16(22)19-11-9-18(10-12-19)14(15(20)21)13-7-5-4-6-8-13/h4-8,14H,9-12H2,1-3H3,(H,20,21)
347186-49-6Relevant articles and documents
Discovery and hit-to-lead evaluation of piperazine amides as selective, state-dependent NaV1.7 inhibitors
Sparling, Brian A.,Yi,Able,Bregman,DiMauro, Erin F.,Foti,Gao,Guzman-Perez,Huang,Jarosh,Kornecook,Ligutti,Milgram,Moyer,Youngblood,Yu,Weiss
, p. 744 - 754 (2017/04/27)
NaV1.7 is a particularly compelling target for the treatment of pain. Herein, we report the discovery and evaluation of a series of piperazine amides that exhibit state-dependent inhibition of NaV1.7. After demonstrating significant pharmacodynamic activity with early lead compound 14 in a NaV1.7-dependent behavioural mouse model, we systematically established SAR trends throughout each sector of the scaffold. The information gleaned from this modular analysis was then applied additively to quickly access analogues that encompass an optimal balance of properties, including NaV1.7 potency, selectivity over NaV1.5, aqueous solubility, and microsomal stability.
