34753-27-0

Basic information

• Product Name: 6-PHENYL-3(2H)-PYRIDAZINONE-4-CARBOXYLIC ACID ETHYL ESTER
• Synonyms: ETHYL 3-OXO-6-PHENYL-2,3-DIHYDRO-4-PYRIDAZINECARBOXYLATE;6-PHENYL-3(2H)-PYRIDAZINONE-4-CARBOXYLIC ACID ETHYL ESTER;Ethyl 6-phenyl-2H-pyridazin-3-one-4-carboxylate;ethyl 3-oxo-6-phenyl-2,3-dihydropyridazine-4-carboxylate;2,3-dihydro-3-oxo-6-phenyl-4-Pyridazinecarboxylic acid Ethyl ester;Ethyl3-hydroxy-6-phenylpyridazine-4-carboxylate
• CAS NO: 34753-27-0
• Molecular Formula: C₁₃H₁₂N₂O₃
• Molecular Weight: 244.25
• Mol File: 34753-27-0.mol
• Article Data: 5

Chemical Properties

• Boiling Point: °Cat760mmHg
• Flash Point: °C
• Appearance: /
• Density: 1.25g/cm³
• Refractive Index: 1.598
• CAS DataBase Reference: 6-PHENYL-3(2H)-PYRIDAZINONE-4-CARBOXYLIC ACID ETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 6-PHENYL-3(2H)-PYRIDAZINONE-4-CARBOXYLIC ACID ETHYL ESTER(34753-27-0)
• EPA Substance Registry System: 6-PHENYL-3(2H)-PYRIDAZINONE-4-CARBOXYLIC ACID ETHYL ESTER(34753-27-0)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 34753-27-0(Hazardous Substances Data)

Usage

Uses

Ethyl 3-oxo-6-phenyl-2,3-dihydro-4-pyridazinecarboxylate is used as a reactant in the chlorination and amidation of 3-?aminopyridazine derivatives with atypical antidepressant, serotonergic and dopaminergic activity.

InChI:InChI=1/C13H12N2O3/c1-2-18-13(17)10-8-11(14-15-12(10)16)9-6-4-3-5-7-9/h3-8H,2H2,1H3,(H,15,16)

Upstream product

• 94011-50-4 ethyl 3-oxo-6-phenyl-2,3,4,5-tetrahydropyridazine-4-carboxylate 
• 3709-20-4 dimethyl 2-phenyl-1,1-cyclopropanedicarboxylate 
• 105-53-3 diethyl malonate 
• 70-11-1 α-bromoacetophenone 
• 94011-49-1 diethyl phenacylmalonate 
• 80989-82-8 diethyl 2-hydroxy-2-(2-oxo-2-phenylethyl)malonate 

Downstream Products

• 404933-59-1 4-(4-morpholinoethylaminocarbonyl)-6-phenyl-3-(2H)-pyridazinone hydrochloride 
• 89868-06-4 4-amino-6-phenyl-3(2H)-pyridazinone 
• 94011-81-1 3-(2-morpholinoethylamino)-4-cyano-6-phenylpyridazine dihydrochloride 
• 94011-64-0 3-chloro-6-phenylpyridazine-4-carbonitrile 

Relevant articles and documents

Design, synthesis and bioevaluation of 3-oxo-6-aryl-2,3-dihydropyridazine-4-carbohydrazide derivatives as novel xanthine oxidase inhibitors

In view of expanding the structure activity relationship of xanthine oxidase inhibitors, a series of 3-oxo-6-aryl-2,3-dihydropyridazine-4-carbohydrazide/carboxylic acid derivatives were designed by molecular docking and synthesized. All the target compoun

New pyridazinone-4-carboxamides as new cannabinoid receptor type-2 inverse agonists: Synthesis, pharmacological data and molecular docking

In the last few years, cannabinoid type-2 receptor (CB2R) selective ligands have shown a great potential as novel therapeutic drugs in several diseases. With the aim of discovering new selective cannabinoid ligands, a series of pyridazinone-4-c

3-Aminopyridazine derivatives with atypical antidepressant, serotonergic, and dopaminergic activities

Minaprine [3[(β-morpholinoethyl)amino]4-methyl-6-phenylpyridazine dihydrochloride] is active in most animal models of depression and exhibits in vivo a dual dopaminomimetic and serotoninomimetic activity profile. In an attempt to dissociate these two effe