34761-09-6

Basic information

• Product Name: 3-AMINO-BENZO[B]THIOPHENE-2-CARBOXYLIC ACID ETHYL ESTER
• Synonyms: AKOS 92613;3-AMINO-BENZO[B]THIOPHENE-2-CARBOXYLIC ACID ETHYL ESTER;Ethyl 3-amino-1-benzothiophene-2-carboxylate;3-amino-2-benzothiophenecarboxylic acid ethyl ester;3-aminobenzothiophene-2-carboxylic acid ethyl ester;ethyl 3-aminobenzothiophene-2-carboxylate
• CAS NO: 34761-09-6
• Molecular Formula: C₁₁H₁₁NO₂S
• Molecular Weight: 221.28
• Mol File: 34761-09-6.mol
• Article Data: 15

Chemical Properties

• Melting Point: ca 82℃ subl.
• Boiling Point: 373.4±22.0 °C(Predicted)
• Appearance: /
• Density: 1.303±0.06 g/cm3(Predicted)
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 0.83±0.10(Predicted)
• CAS DataBase Reference: 3-AMINO-BENZO[B]THIOPHENE-2-CARBOXYLIC ACID ETHYL ESTER(CAS DataBase Reference)
• NIST Chemistry Reference: 3-AMINO-BENZO[B]THIOPHENE-2-CARBOXYLIC ACID ETHYL ESTER(34761-09-6)
• EPA Substance Registry System: 3-AMINO-BENZO[B]THIOPHENE-2-CARBOXYLIC ACID ETHYL ESTER(34761-09-6)

Safety Data

• Hazardous Substances Data: 34761-09-6(Hazardous Substances Data)

Usage

General Description

3-Amino-benzo[b]thiophene-2-carboxylic acid ethyl ester is a chemical compound with the molecular formula C12H11NO2S. It is an ethyl ester derivative of 3-amino-benzo[b]thiophene-2-carboxylic acid, which is a heterocyclic aromatic compound. This chemical is commonly used in pharmaceutical research as a building block for the synthesis of various bioactive compounds and potential drug candidates. Its unique molecular structure and functional groups make it useful for the development of new medicines and pharmaceuticals. Additionally, it has potential applications in the field of organic synthesis and medicinal chemistry.

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Downstream Products

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Relevant articles and documents

Synthesis and characterization of 1,2,4-triazolo[1,5-a]pyrimidine-2-carboxamide-based compounds targeting the PA-PB1 interface of influenza A virus polymerase

Influenza viruses (Flu) are responsible for seasonal epidemics causing high rates of morbidity, which can dramatically increase during severe pandemic outbreaks. Antiviral drugs are an indispensable weapon to treat infected people and reduce the impact on

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The paper focussed on a step-by-step structural modification of a cycloheptathiophene-3-carboxamide derivative recently identified by us as reverse transcriptase (RT)-associated ribonuclease H (RNase H) inhibitor. In particular, its conversion to a 2-aryl-cycloheptathienoozaxinone derivative and the successive thorough exploration of both 2-aromatic and cycloheptathieno moieties led to identify oxazinone-based compounds as new anti-RNase H chemotypes. The presence of the catechol moiety at the C-2 position of the scaffold emerged as critical to achieve potent anti-RNase H activity, which also encompassed anti-RNA dependent DNA polymerase (RDDP) activity for the tricyclic derivatives. Benzothienooxazinone derivative 22 resulted the most potent dual inhibitor exhibiting IC50s of 0.53 and 2.90 μM against the RNase H and RDDP functions. Mutagenesis and docking studies suggested that compound 22 binds two allosteric pockets within the RT, one located between the RNase H active site and the primer grip region and the other close to the DNA polymerase catalytic centre.

COMPOUND FOR ORGANIC OPTOELECTRIC DEVICE, ORGANIC OPTOELECTRIC DEVICE AND DISPLAY DEVICE

The present invention relates to a compound for an organic photoelectronic device, the organic photoelectronic device comprising the same, and a display device comprising the organic photoelectronic device, wherein the compound for an organic photoelectronic device is represented by chemical formula 1. In the chemical formula 1, A1, A2, X, R1 to R5, L1 to L3 are the same as defined in the specification.