348-51-6Relevant articles and documents
AROMATIC FLUORINE CHEMISTRY. PART 2. PREPARATION OF CHLOROFLUOROBENZENES VIA FLUORINATION OF DICHLOROBENZENES WITH KF
Pews, R. G.,Gall, J. A.
, p. 371 - 375 (1990)
The 1,2-, 1,3-, and 1,4-chlorofluorobenzenes have been prepared via KF exchange on the corresponding dichlorobenzenes.
Deaminative fluorination of anilines using potassium hydrogen fluoride and silicon tetrafluoride
Tamura, Masanori,Shibakami, Motonari,Kurosawa, Shigeru,Arimura, Takashi,Sekiya, Akira
, p. 95 - 96 (1996)
It has been found that the combination of potassium hydrogen fluoride and silicon tetrafluoride works as an efficient fluorinating agent for the deaminative fluorination of anilines. A one-pot diazotization of anilines followed by fluoro-dediazoniation proceeds with this combination of the reagents and t-butyl nitrite to afford fluoroarenes.
Lewis Acid Mediated Fluorinations of Aromatic Substrates
Purrington, Suzanne T.,Woodard, Daniel L.
, p. 142 - 145 (1991)
Direct fluorination of aromatic substrates, PhZ (Z=Cl, CHO, CH(OCH2)2, NO2, CO2CH2CH3, OH, NHCH3, OCH3, CH3) in the presence and absence of BCl3 or AlCl3, has been investigated.For PhCl and PhOH, inclusion of boron trichloride increased the percent conversion and the amount of para product.However, AlCl3 caused an increase in the ortho regioselectivity in the reaction with chlorobenzene.For PhCHO, inclusion of a Lewis acid decreased the percent conversion.In the presence of BCl3, the ethylene glycol acetal of PhCHO gave only ortho and para fluorinated derivatives with improved conversion.PhCO2CH2CH3 was unaffected by the inclusion of Lewis acid while the percentage conversion of PhNO2 increased only slightly.Fluorination of PhNHCH3, PhOCH3, or PhCH3 gave complex reaction mixtures. p-Nitroanisole gave rise to only 2-fluoro-4-nitroanisole in the presence or absence of either Lewis acid.
Two-step regioselective synthesis of 1,2-difluorobenzenes from chlorotrifluoroethylene and buta-l,3-dienes
Lipkind, M. B.,Nefedov, O. M.,Volchkov, N. V.
, p. 68 - 75 (2020/04/21)
The gas-phase copyrolysis of chlorotrifluoroethylene with buta-1,3-diene, penta-1,3-diene, or isoprene in a flow reactor at 440–480°C gave 4-chloro-4,5,5-trifluorocyclohex-1-enes. The latter treated with aqueous KOH under condition of phase-transfer catalysis were selectively converted into 1,2-difluorobenzene, 2,3-difluorotoluene, or 3,4-difluorotoluene.
PROCESS FOR THE PREPARATION OF ORGANIC HALIDES
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Paragraph 00146, (2017/08/01)
The present invention provides a halo-de-carboxylation process for the preparation of organic chlorides, organic bromides and mixtures thereof, from their corresponding carboxylic acids, using a chlorinating agent selected from trichloroisocyanuric acid (TCCA), dichloroisocyanuric acid (DCCA), or combination thereof, and a brominating agent.