34827-33-3 Usage
Description
Norsalsolinol is a naturally occurring chemical compound derived from the oxidative breakdown of dopamine in the brain. It has been implicated in neurological disorders such as Parkinson's disease and addiction, exhibiting neurotoxic and neuroinflammatory effects that contribute to the degeneration of dopaminergic neurons. Its role in reinforcing drug-seeking behavior highlights its importance in neuroscience and addiction research, making it a significant target for the development of new treatments and therapies.
Uses
Used in Neuroscience Research:
Norsalsolinol is utilized as a research compound for studying the mechanisms underlying neurological disorders and addiction. Its involvement in the degeneration of dopaminergic neurons and its reinforcing effects on drug-seeking behavior make it a valuable tool for understanding the pathophysiology of these conditions.
Used in Drug Development:
Norsalsolinol serves as a target for the development of new treatments and therapies aimed at mitigating its neurotoxic and neuroinflammatory effects. By modulating norsalsolinol's impact on the brain, researchers can potentially develop interventions to treat or prevent the progression of neurological disorders and addiction.
Used in Diagnostics:
Norsalsolinol may be employed as a biomarker for the early detection and monitoring of neurological disorders and addiction. Its presence and levels in biological samples could provide insights into the severity and progression of these conditions, aiding in the development of personalized treatment plans.
Used in Toxicology Studies:
Norsalsolinol is used as a compound of interest in toxicology studies, where its effects on the brain and nervous system are examined. Understanding its toxicity can help in assessing the risks associated with exposure to norsalsolinol and inform safety guidelines for potential therapeutic agents targeting its pathways.
Check Digit Verification of cas no
The CAS Registry Mumber 34827-33-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 3,4,8,2 and 7 respectively; the second part has 2 digits, 3 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 34827-33:
(7*3)+(6*4)+(5*8)+(4*2)+(3*7)+(2*3)+(1*3)=123
123 % 10 = 3
So 34827-33-3 is a valid CAS Registry Number.
InChI:InChI=1/C9H11NO2/c11-8-3-6-1-2-10-5-7(6)4-9(8)12/h3-4,10-12H,1-2,5H2
34827-33-3Relevant articles and documents
6,7-Dihydroxy-1,2,3,4-tetrahydroisoquinoline formation by iron mediated dopamine oxidation: A novel route to endogenous neurotoxins under oxidative stress conditions
Napolitano, Alessandra,Pezzella, Alessandro,Prota, Giuseppe
, p. 2833 - 2836 (2007/10/03)
Aerobic oxidation of dopamine mediated by iron ions gives 6,7- dihydroxy-1,2,3,4-tetrahydroisoquinoline (2) and 3,4-dihydroxybenzaldehyde (4) in yields up to 10% and 15%, respectively. Based on 13C labelling experiments, a reaction mechanism is proposed involving oxidative fission of the dopamine side chain to give 4 and formaldehyde, the latter giving 2 by Pictet-Spengler condensation with dopamine. This provides a novel route to endogenous generation of neurotoxic isoquinoline alkaloids under oxidative stress conditions.
