348596-90-7Relevant articles and documents
Azolium-linked cyclophanes: A comprehensive examination of conformations by 1H NMR spectroscopy and structural studies
Baker, Murray V.,Bosnich, Mark J.,Brown, David H.,Byrne, Lindsay T.,Hesler, Valerie J.,Skelton, Brian W.,White, Allan H.,Williams, Charlotte C.
, p. 7640 - 7652 (2004)
The synthesis and characterization of a series of azolium-linked cyclophanes are reported. The cyclophanes consist of two azolium groups (17 examples) or three imidazolium groups (1 example) linked to two benzenoid units (benzene, naphthalene, p-xylene, m
Inclusion of a dithiadiazolyl radical in a seemingly non-porous solid
Nikolayenko, Varvara I,Barbour, Leonard J,Arauzo, Ana,Campo, Javier,Rawson, Jeremy M,Haynes, Delia A.
, p. 11310 - 11313 (2017)
Inclusion of the dithiadiazolyl radical PhCNSSN into the dynamically porous metallocycle [Cu2(L1)2Cl4], where L1 is the bidentate ligand 1,3-bis(imidazol-1-ylmethyl)-2,4,6-trimethylbenzene, has been achieved by gas phase diffusion. Single crystal X-ray diffraction, powder X-ray diffraction, UV-visible spectroscopy, EPR and SQUID magnetometry studies confirm inclusion of the radical into this seemingly non-porous material, and illustrate the antiferromagnetic coupling between the paramagnetic host and guest species. The radical guest is readily released by heating or by the addition of solvent (CH2Cl2).
Ag(I)-N-heterocyclic carbene complexes of N-allyl substituted imidazol-2-ylidenes with ortho-, meta- and para-xylyl spacers: Synthesis, crystal structures and in vitro anticancer studies
Haque, Rosenani A.,Ghdhayeb, Mohammed Z.,Salman, Abbas Washeel,Budagumpi, Srinivasa,Khadeer Ahamed, Mohamed B.,Abdul Majid, Amin M.S.
, p. 113 - 119 (2012)
A series of N-allyl substituted xylyl-linked imidazolium salts (7-10) and their respective Ag(I)-N-heterocyclic carbene (NHC) complexes (11-14) have been synthesized and characterized by a number of spectral and analytical techniques. Molecular structure of complexes 13 and 14 were established by single-crystal X-ray diffraction method. The in vitro anticancer activity of all imidazolium salts and their Ag(I)-carbene complexes were investigated using human colorectal (HCT 116) cancer cell lines. Imidazolium salts displayed no activity for HCT 116 cell lines, except for 9; yielding IC50 value of 15.9 μM. Ag(I)-carbene complexes 12-14 showed exceptionally good activity (0.9-1.3 μM) against tested cancer cell lines. Furthermore, complex 11 displayed relatively good anticancer activity with IC50 value of 5.2 μM, which is almost equal to standard used.
