349087-34-9

Basic information

• Product Name: JX401
• Synonyms: JX401;1-[2-Methoxy-4-(methylthio)benzoyl]-4-benzylpiperidine;1-[2-Methoxy-4-(methylthio)benzoyl]-4-(phenylmethyl)piperidine;p38 MAP Kinase Inhibitor VI, JX401
• CAS NO: 349087-34-9
• Molecular Formula: C21H25NO2S
• Molecular Weight: 355.49
• Product Categories: Intracellular Signaling
• Mol File: 349087-34-9.mol
• Article Data: 0

Chemical Properties

• Boiling Point: 537.3 °C at 760 mmHg
• Flash Point: 278.8 °C
• Appearance: /
• Density: 1.17 g/cm³
• Vapor Pressure: 1.28E-11mmHg at 25°C
• Refractive Index: 1.611
• Storage Temp.: Store at RT
• Solubility: Soluble in DMSO (up to 25 mg/ml) or in Ethanol (up to 20 mg/ml).
• Stability: Stable for 2 years from date of purchase as supplied. PROTECT FROM MOISTURE. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.
• CAS DataBase Reference: JX401(CAS DataBase Reference)
• NIST Chemistry Reference: JX401(349087-34-9)
• EPA Substance Registry System: JX401(349087-34-9)

Safety Data

• Hazard Codes: N
• Statements: 50/53
• Safety Statements: 60-61
• RIDADR: UN 3077 9/PG 3
• Hazardous Substances Data: 349087-34-9(Hazardous Substances Data)

Usage

Description

JX401 (349087-34-9) is a potent, cell-permeable inhibitor of p38α (IC50 = 32 nM). No inhibition of p38β was observed at 10 μM.

Uses

Different sources of media describe the Uses of 349087-34-9 differently. You can refer to the following data:
1. JX-401 is a potent, reversible inhibitor of the p38α isoform of MAP kinase (IC50 = 32 nM). It does not inhibit the p38γ isoform. JX-401 is effective in mammalian cells, as it blocks the differentiation of myoblasts into myotubes.[Cayman Chemical]
2. JX-401 is an inhibitor of p38α isoform MAP kinase, blocks the differentiation of myoblasts and myotubes.

Biological Activity

Potent, reversible inhibitor of p38 α that displays no activity on the p38 γ isoform (IC 50 values are 32 nM and > 10 μ M respectively). Inhibits the differentiation of myoblasts to myotubes in mammalian cells in culture.

References

1) Friedmann et al. (2006), JX401,a p38α inhibitor containing a 4-benzylpiperidine motif, identified via a novel screening system in yeast; Mol. Pharmacol., 70 1395.

InChI:InChI=1/C21H25NO2S/c1-24-20-15-18(25-2)8-9-19(20)21(23)22-12-10-17(11-13-22)14-16-6-4-3-5-7-16/h3-9,15,17H,10-14H2,1-2H3