349092-70-2

Basic information

• Product Name: 2-BROMO-N,N-DIBUTYLBENZAMIDE
• Synonyms: 2-Bromo-N,N-dibutylbenzamide97%;2-BROMO-N,N-DIBUTYLBENZAMIDE;N,N-DIBUTYL 2-BROMOBENZAMIDE;2-Bromo-N,N-dibutylbenzamide 97%
• CAS NO: 349092-70-2
• Molecular Formula: C15H22BrNO
• Molecular Weight: 312.24528
• Product Categories: blocks;Bromides;Carboxes
• Mol File: 349092-70-2.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 403.2 °C at 760 mmHg
• Flash Point: 197.7 °C
• Appearance: /
• Density: 1.201 g/cm³
• Vapor Pressure: 1.03E-06mmHg at 25°C
• Refractive Index: 1.528
• Storage Temp.: Keep Cold
• PKA: -1.42±0.70(Predicted)
• CAS DataBase Reference: 2-BROMO-N,N-DIBUTYLBENZAMIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-BROMO-N,N-DIBUTYLBENZAMIDE(349092-70-2)
• EPA Substance Registry System: 2-BROMO-N,N-DIBUTYLBENZAMIDE(349092-70-2)

Safety Data

• Hazard Codes: Xi
• Hazardous Substances Data: 349092-70-2(Hazardous Substances Data)

Usage

General Description

2-Bromo-N,N-dibutybenzamide is a chemical compound with the molecular formula C14H22BrNO. It is a white solid that is soluble in organic solvents and is commonly used as an intermediate in the synthesis of pharmaceuticals and agrochemicals. 2-BROMO-N,N-DIBUTYLBENZAMIDE is a derivative of benzamide and contains a bromine atom and two butyl groups attached to the amide nitrogen atom. It is primarily used as a building block in organic synthesis and as a reagent in research and development. The compound's properties and applications make it a valuable tool in the field of chemical science.

InChI:InChI=1/C15H22BrNO/c1-3-5-11-17(12-6-4-2)15(18)13-9-7-8-10-14(13)16/h7-10H,3-6,11-12H2,1-2H3

Upstream product

• 111-92-2 dibutylamine 
• 88-65-3 2-bromobenzoic-acid 
• 6141-82-8 N,N-dibutylchlorothiophosphoramidate 
• 6630-33-7 ortho-bromobenzaldehyde 

Downstream Products

• 1616609-93-8 2-(benzo[d][1,3]dioxol-5-yl)-N,N-dibutylbenzamide 

Relevant articles and documents

Efficient modulation of γ-aminobutyric acid type a receptors by piperine derivatives

Piperine activates TRPV1 (transient receptor potential vanilloid type 1 receptor) receptors and modulates γ-aminobutyric acid type A receptors (GABAAR). We have synthesized a library of 76 piperine analogues and analyzed their effects on GABAAR by means of a two-microelectrode voltage-clamp technique. GABAAR were expressed in Xenopus laevis oocytes. Structure-activity relationships (SARs) were established to identify structural elements essential for efficiency and potency. Efficiency of piperine derivatives was significantly increased by exchanging the piperidine moiety with either N,N-dipropyl, N,N-diisopropyl, N,N-dibutyl, p-methylpiperidine, or N,N-bis(trifluoroethyl) groups. Potency was enhanced by replacing the piperidine moiety by N,N-dibutyl, N,N-diisobutyl, or N,N-bistrifluoroethyl groups. Linker modifications did not substantially enhance the effect on GABAAR. Compound 23 [(2E,4E)-5-(1,3-benzodioxol-5-yl)-N,N-dipropyl-2,4-pentadienamide] induced the strongest modulation of GABAA (maximal GABA-induced chloride current modulation (IGABA-max = 1673% ± 146%, EC 50 = 51.7 ± 9.5 μM), while 25 [(2E,4E)-5-(1,3-benzodioxol- 5-yl)-N,N-dibutyl-2,4-pentadienamide] displayed the highest potency (EC 50 = 13.8 ± 1.8 μM, IGABA-max = 760% ± 47%). Compound 23 induced significantly stronger anxiolysis in mice than piperine and thus may serve as a starting point for developing novel GABA AR modulators.