349103-24-8Relevant articles and documents
Synthesis and application in asymmetric C-C bond formation of solution phase ligand libraries of monodentate phosphoramidites
Duursma, Ate,Lefort, Laurent,Boogers, Jeroen A.F.,De Vries, Andre H.M.,De Vries, Johannes G.,Minnaard, Adriaan J.,Feringa, Ben L.
, p. 1682 - 1684 (2004)
The synthesis of solution phase libraries of chiral monodentate phosphoramidite by using the automated parallel protocol was analyzed. It was observed that the method leads to the analysis of effective enantioselective catalysts for tranformations and association with the monodentate ligand combination approach. The automated parallel protocol provided a powerful tool for the combinatorial asymmetric catalysis. The chromatography was performed at the end of the phosphoramidite synthesis by a filtration process, due to more simple automated procedure.
Rapid identification of a scalable catalyst for the asymmetric hydrogenation of a sterically demanding aryl enamide
Lefort, Laurent,Boogers, Jeroen A. F.,Kuilman, Thijs,Vijn, Robert Jan,Janssen, John,Straatman, Harrie,De Vries, Johannes G.,De Vries, Andre H. M.
supporting information; experimental part, p. 568 - 573 (2011/07/08)
High throughput screening was used to find a cost-effective and scalable catalyst for the asymmetric hydrogenation of a sterically demanding enamide as an intermediate towards a new potent melanocortin receptor agonist useful in the treatment of obesity.
Catalytic asymmetric alkynylation and arylation of aldehydes by an H 8-binaphthyl-based amino alcohol ligand
Ruan, Jiwu,Lu, Gui,Xu, Lijing,Li, Yue-Ming,Chan, Albert S. C.
experimental part, p. 76 - 84 (2009/04/11)
A novel chiral H8-1,1'-binaphthyl-based amino alcohol ligand (1Ra,2S,3R)-2 has been synthesized and applied in the direct nucleophilic addition of organozincs (alkynylzinc and arylzinc prepared in situ) to aldehydes, yielding the corresponding optically active propargylic alcohols and diarylmethanols in high yields and good to excellent enantioselectivities. For the asymmetric arylation reaction, one catalyst (1Ra,2S,3R)-2 can afford both enantiomers of many pharmaceutically interesting diarylmethanols by a proper combination of various arylzinc reagents and aldehydes.