34927-63-4Relevant articles and documents
Bis-basic ketones of fluorene and fluorenone
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, (2008/06/13)
The novel bis-basic ketones of fluorene and fluorenone of the present invention have antiviral activity when administered orally and parenterally. These compounds are represented by the following formula: STR1 wherein Z is oxygen or H2 ; each A is a straight or branched alkylene chain having from 1 to about 6 carbon atoms; and each Y is A. the group STR2 wherein R1 and R2 are individually hydrogen, (lower)alkyl having from 1 to about 6 carbon atoms, cycloalkyl having from 3 to 6 carbon atoms, alkenyl of from 3 to 6 carbon atoms and having the vinyl unsaturation in other than the 1-position of the alkenyl group; or B. the group STR3 WHEREIN N IS A WHOLE INTEGER FROM 4 TO 6, AND R3 is hydrogen, (lower)alkyl of 1 to about 4 carbon atoms, phenyl, or benzyl and can be linked to any one of the carbon atoms of the heterocyclic group; or C. the group STR4 wherein X is oxygen or NR4, and R4 is hydrogen or (lower)alkyl of from 1 to about 4 carbon atoms; or D. the group STR5 WHEREIN P IS A WHOLE INTEGER FROM 2 TO 3, AND M IS A WHOLE INTEGER FROM 1 TO 2; OR A PHARMACEUTICALLY ACCEPTABLE ACID ADDITION SALT OF SAID BASE. These new compounds may be prepared by several different methods which are described.